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Li X, Chen H, Selvaraj MSunitha, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, et al. A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. bioRxiv. 2023 .

Lin H, Wang M, Brody JA, Bis JC, Dupuis J, Lumley T, McKnight B, Rice KM, Sitlani CM, Reid JG, et al. Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014 ;7(3):335-43.

Benke KS, Wu Y, Fallin DM, Maher B, Palmer LJ. Strategy to control type I error increases power to identify genetic variation using the full biological trajectory. Genet Epidemiol. 2013 ;37(5):419-30.

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 .

Lumley T, Kronmal RA, Cushman M, Manolio TA, Goldstein S. A stroke prediction score in the elderly: validation and Web-based application. J Clin Epidemiol. 2002 ;55(2):129-36.

Elkins JS, O'Meara ES, Longstreth WT, Carlson MC, Manolio TA, Johnston SC. Stroke risk factors and loss of high cognitive function. Neurology. 2004 ;63(5):793-9.

Feinberg WM, Kronmal RA, Newman AB, Kraut MA, Bovill EG, Cooper L, Hart RG. Stroke risk in an elderly population with atrial fibrillation. J Gen Intern Med. 1999 ;14(1):56-9.

Kulminski AM, Huang J, Loika Y, Arbeev KG, Bagley O, Yashkin A, Duan M, Culminskaya I. Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes. Aging (Albany NY). 2018 ;10(3):492-514.

Wang H, Dombroski BA, Cheng PL, Tucci A, Si YQ, Farrell JJ, Tzeng JY, Leung YY, Malamon JS, Wang LS, et al. {Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects. medRxiv. 2023 .

Lee WP, Wang H, Dombroski B, Cheng PL, Tucci A, Si YQ, Farrell J, Tzeng JY, Leung YY, Malamon J, et al. {Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects. Res Sq. 2023 .

Davies G, Lam M, Harris SE, Trampush JW, Luciano M, W Hill D, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018 ;9(1):2098.

Psaty BM, Delaney JA, Arnold AM, Curtis LH, Fitzpatrick AL, Heckbert SR, McKnight B, Ives D, Gottdiener JS, Kuller LH, et al. Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study. Circulation. 2016 ;133(2):156-64.

Larkin EK, Patel SR, Zhu X, Tracy RP, Jenny NS, Reiner AP, Walston J, Redline S. Study of the relationship between the interleukin-6 gene and obstructive sleep apnea. Clin Transl Sci. 2010 ;3(6):337-9.

van der Hagen PB, Folsom AR, Jenny NS, Heckbert SR, O'Meara ES, Reich LM, Rosendaal FR, Cushman M. Subclinical atherosclerosis and the risk of future venous thrombosis in the Cardiovascular Health Study. J Thromb Haemost. 2006 ;4(9):1903-8.

Kuller LH, Lopez OL, Gottdiener JS, Kitzman DW, Becker JT, Chang Y, Newman AB. Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly. J Am Heart Assoc. 2017 ;6(7).

Rosano C, Kuller LH, Chung H, Arnold AM, Longstreth WT, Newman AB. Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J Am Geriatr Soc. 2005 ;53(4):649-54.

Kuller LH, Lopez OL, Mackey RH, Rosano C, Edmundowicz D, Becker JT, Newman AB. Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years. J Am Coll Cardiol. 2016 ;67(9):1013-22.

Chaves PHM, Kuller LH, O'Leary DH, Manolio TA, Newman AB. Subclinical cardiovascular disease in older adults: insights from the Cardiovascular Health Study. Am J Geriatr Cardiol. 2004 ;13(3):137-51.

Kuller LH, Shemanski L, Psaty BM, Borhani NO, Gardin J, Haan MN, O'Leary DH, Savage PJ, Tell GS, Tracy R. Subclinical disease as an independent risk factor for cardiovascular disease. Circulation. 1995 ;92(4):720-6.

Collet T-H, Gussekloo J, Bauer DC, Elzen WPJ den, Cappola AR, Balmer P, Iervasi G, Asvold BO, Sgarbi JA, Völzke H, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012 ;172(10):799-809.

Rodondi N, Elzen WPJ den, Bauer DC, Cappola AR, Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi M, Collet T-H, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010 ;304(12):1365-74.

Chaker L, Baumgartner C, Elzen WPJ den, Ikram AM, Blum MR, Collet T-H, Bakker SJL, Dehghan A, Drechsler C, Luben RN, et al. Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. J Clin Endocrinol Metab. 2015 ;100(6):2181-91.

Garin MC, Arnold AM, Lee JS, Tracy RP, Cappola AR. Subclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study. J Clin Endocrinol Metab. 2014 ;99(4):1220-6.

Blum MR, Bauer DC, Collet T-H, Fink HA, Cappola AR, da Costa BR, Wirth CD, Peeters RP, Asvold BO, Elzen WPJ den, et al. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA. 2015 ;313(20):2055-65.

Garin MC, Arnold AM, Lee JS, Robbins J, Cappola AR. Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the cardiovascular health study. J Clin Endocrinol Metab. 2014 ;99(8):2657-64.

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