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Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the cardiovascular health study.
Friday,2014-07-18 14:40 America/Los_Angeles — eenright
| Title | Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Garin, MC, Arnold, AM, Lee, JS, Robbins, J, Cappola, AR |
| Journal | J Clin Endocrinol Metab |
| Volume | 99 |
| Issue | 8 |
| Pagination | 2657-64 |
| Date Published | 2014 Aug |
| ISSN | 1945-7197 |
| Keywords | Absorptiometry, Photon, Aged, Aged, 80 and over, Asymptomatic Diseases, Bone Density, Cardiovascular System, Cohort Studies, Cross-Sectional Studies, Female, Hip Fractures, Humans, Male, Osteoporotic Fractures, Risk Factors, Sex Factors, Thyroid Diseases |
| Abstract | <p><b>BACKGROUND: </b>Subclinical thyroid dysfunction is common in the elderly, yet its relationship with hip fracture and bone mineral density (BMD) is unclear.</p><p><b>OBJECTIVE: </b>We examined the association between endogenous subclinical hyper- and hypothyroidism and hip fracture and BMD in older adults.</p><p><b>METHODS: </b>A total of 4936 US individuals 65 years old or older enrolled in the Cardiovascular Health Study and not taking thyroid preparations were included. Analyses of incident hip fracture were performed by thyroid status, over a median follow-up of 12 years. A cross-sectional analysis of thyroid status and BMD was performed in a subset of 1317 participants who had dual-energy x-ray absorptiometry scans. Models were adjusted for risk factors and stratified by sex.</p><p><b>RESULTS: </b>No association was found between subclinical hypothyroidism and incident hip fracture compared with euthyroidism, when assessed at a single time point or persisting at two time points, in either women [hazard ratio (HR) 0.91, 95% confidence interval (CI) 0.69-1.20 for a single and HR 0.79, 95% CI 0.52-1.21 for two time points] or men (HR 1.27, 95% CI 0.82-1.95 for a single and HR 1.09, 95% CI 0.57-2.10 for two time points). Likewise, no association was found between subclinical hyperthyroidism and incident hip fracture in either sex (HR 1.11, 95% CI 0.55-2.25 in women and HR 1.78, 95% CI 0.56-5.66 in men). No association was found between subclinical thyroid dysfunction and BMD at the lumbar spine, total hip, or femoral neck sites.</p><p><b>CONCLUSIONS: </b>Our data suggest no association between subclinical hypothyroidism or subclinical hyperthyroidism and hip fracture risk or BMD in older men and women. Additional data are needed to improve the precision of estimates for subclinical hyperthyroidism and in men.</p> |
| DOI | 10.1210/jc.2014-1051 |
| Alternate Journal | J. Clin. Endocrinol. Metab. |
| PubMed ID | 24878045 |
| PubMed Central ID | PMC4121038 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01AG032317 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States T32DK007314 / DK / NIDDK NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG032317 / AG / NIA NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States T32 DK007314 / DK / NIDDK NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |