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Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults.
Tuesday,2012-11-06 12:09 America/Los_Angeles — eenright
| Title | Insulin-like growth factor-(IGF)-axis, inflammation, and glucose intolerance among older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Rajpathak, SN, McGinn, AP, Strickler, HD, Rohan, TE, Pollak, M, Cappola, AR, Kuller, L, Xue, XN, Newman, AB, Strotmeyer, ES, Psaty, BM, Kaplan, RC |
| Journal | Growth Horm IGF Res |
| Volume | 18 |
| Issue | 2 |
| Pagination | 166-73 |
| Date Published | 2008 Apr |
| ISSN | 1096-6374 |
| Keywords | Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Female, Glucose Intolerance, Humans, Inflammation, Insulin-Like Growth Factor Binding Proteins, Male, Signal Transduction, Somatomedins |
| Abstract | <p>Increasing evidence suggests that the insulin-like growth factor (IGF)-axis may play a role in glucose metabolism and may also be associated with systemic inflammation. The aim of this study was to evaluate the association of insulin-like growth factor-1 (IGF-I) and its binding proteins, IGFBP-1 and IGFBP-3, with glucose intolerance and inflammation among older adults. We conducted a cross-sectional analysis in a in a random subsample (n=922) of the Cardiovascular Health Study (CHS), a prospective cohort of men and women > or = 65 years. Mean IGFBP-1 levels were significantly lower in older adults with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes compared to those with normal fasting and post-load glucose. High IGFBP-1 was associated with a reduced prevalence of IGT and IFG; the multivariable OR between extreme quartiles of IGFBP-1 was 0.60 (95% CI: 0.37, 0.95; p-trend: 0.03) for IGT and 0.41 (95% CI: 0.26, 0.64; p-trend: <0.01) for IFG. We did not find any significant association between IGF-I and glucose intolerance in this study and the association for IGFBP-3 was less clear. However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels. We conclude that among adults > or = 65 years, low IGFBP-1 levels are associated with increased prevalence of glucose intolerance. We did not confirm prior associations of low IGF-I with glucose intolerance in this cohort of older individuals.</p> |
| DOI | 10.1016/j.ghir.2007.08.004 |
| Alternate Journal | Growth Horm IGF Res |
| PubMed ID | 17904401 |
| PubMed Central ID | PMC2492581 |
| Grant List | R01 HL075516 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 HL075516-01 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R01HL075516-01 / HL / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States |