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Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Mukamal, KJ, Jenny, NS, Tracy, RP, Siscovick, DS |
| Journal | Am J Clin Nutr |
| Volume | 86 |
| Issue | 2 |
| Pagination | 444-50 |
| Date Published | 2007 Aug |
| ISSN | 0002-9165 |
| Keywords | Aged, Alcohol Drinking, Apolipoprotein E4, Apolipoproteins E, Blood Glucose, C-Reactive Protein, Cohort Studies, Female, Genotype, Humans, Interleukin-6, Male, Promoter Regions, Genetic, Serum Amyloid P-Component |
| Abstract | <p><b>BACKGROUND: </b>Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain.</p><p><b>OBJECTIVE: </b>We determined how alcohol intake and apolipoprotein E (apo E) and IL-6 promoter (IL-6 -174G-->C) polymorphisms interact for concentrations of IL-6 and SAP.</p><p><b>DESIGN: </b>In the Cardiovascular Health Study, 2454 older adults reported their intake of beer, wine, and liquor and underwent measurements of circulating IL-6 and SAP.</p><p><b>RESULTS: </b>Alcohol intake was not associated with IL-6 concentrations among apo E4-negative or IL-6C-positive participants but was positively associated among both apo E4-positive and IL-6C-negative participants (P for trend = 0.02 for both). The corresponding interactions on SAP were not significant for alcohol overall but were similar for liquor intake.</p><p><b>CONCLUSIONS: </b>Among older adults free of clinical cardiovascular disease, specific IL-6 promoter and apo E alleles appeared to confer positive associations of alcohol consumption with IL-6 concentrations. Genetic heterogeneity should be considered in understanding the cardiovascular effects of alcohol intake.</p> |
| DOI | 10.1093/ajcn/86.2.444 |
| Alternate Journal | Am J Clin Nutr |
| PubMed ID | 17684217 |
| PubMed Central ID | PMC2128737 |
| Grant List | N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R21 AA014900 / AA / NIAAA NIH HHS / United States R21 AA014900-02 / AA / NIAAA NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States R21-AA-00499 / AA / NIAAA NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |