You are here
Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Folsom, AR, Cushman, M, Heckbert, SR, Ohira, T, Rasmussen-Torvik, L, Tsai, MY |
| Journal | J Thromb Haemost |
| Volume | 5 |
| Issue | 8 |
| Pagination | 1674-8 |
| Date Published | 2007 Aug |
| ISSN | 1538-7933 |
| Keywords | Alleles, Antigens, Coagulants, Factor VII, Female, Genotype, Humans, Male, Polymorphism, Genetic, Prospective Studies, Risk Factors, Thromboembolism, Venous Thrombosis |
| Abstract | <p><b>BACKGROUND: </b>Most epidemiological studies have found no association between levels of factor (F) VII:C and venous thromboembolism (VTE). Our Longitudinal Investigation of Thromboembolism Etiology (LITE) had, in contrast, reported an independent, increased risk of VTE after 7.8 years of follow-up for those with high baseline levels of FVII:C.</p><p><b>OBJECTIVE: </b>To confirm whether FVII:C is associated with VTE after 12.6 years of follow-up and to examine whether two FVII gene polymorphisms (-670A/C and -402G/A) are related to VTE occurrence.</p><p><b>METHODS: </b>In 19 091 LITE participants with no prior history of VTE or cancer, we measured FVII:C at baseline and identified 404 new VTEs. We also performed a nested case-control study to relate the polymorphisms to VTE (n = 490 without exclusion for cancer or prior VTE).</p><p><b>RESULTS: </b>FVII:C was not independently associated with VTE occurrence after extended follow-up. Multivariable-adjusted rate ratios for VTE were 1.00, 1.00, 0.94, 1.00, and 1.38 (P-trend = 0.48) for the <25th, 25th-49th, 50th-74th, 75th-94th, and >or=95th percentiles of FVII:C, respectively. The -670C and -402A alleles were in high linkage disequilibrium, and both were associated with greater FVII:C levels. However, neither polymorphism was associated with VTE occurrence.</p><p><b>CONCLUSION: </b>After extended follow-up, LITE offers little evidence that a greater FVII level is a risk factor for VTE.</p> |
| DOI | 10.1111/j.1538-7836.2007.02620.x |
| Alternate Journal | J Thromb Haemost |
| PubMed ID | 17663738 |
| Grant List | N01-HC 55015 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 HL59367 / HL / NHLBI NIH HHS / United States |