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Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
Monday,2024-05-13 14:12 America/Los_Angeles — ecterry
| Title | Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Kwak, SHeon, Hernandez-Cancela, RB, DiCorpo, DA, Condon, DE, Merino, J, Wu, P, Brody, JA, Yao, J, Guo, X, Ahmadizar, F, Meyer, M, Sincan, M, Mercader, JM, Lee, S, Haessler, J, Vy, HMy T, Lin, Z, Armstrong, ND, Gu, S, Tsao, NL, Lange, LA, Wang, N, Wiggins, KL, Trompet, S, Liu, S, Loos, RJF, Judy, R, Schroeder, PH, Hasbani, NR, Bos, MM, Morrison, AC, Jackson, RD, Reiner, AP, Manson, JAE, Chaudhary, NS, Carmichael, LK, Chen, Y-DI, Taylor, KD, Ghanbari, M, van Meurs, J, Pitsillides, AN, Psaty, BM, Noordam, R, Do, R, Park, KSoo, J Jukema, W, Kavousi, M, Correa, A, Rich, SS, Damrauer, SM, Hajek, C, Cho, NH, Irvin, MR, Pankow, JS, Nadkarni, GN, Sladek, R, Goodarzi, MO, Florez, JC, Chasman, DI, Heckbert, SR, Kooperberg, C, Dupuis, J, Malhotra, R, de Vries, PS, Liu, C-T, Rotter, JI, Meigs, JB |
| Corporate/Institutional Authors | Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium |
| Journal | Diabetes Care |
| Date Published | 2024 Apr 23 |
| ISSN | 1935-5548 |
| Abstract | <p><b>OBJECTIVE: </b>To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D).</p><p><b>RESEARCH DESIGN AND METHODS: </b>We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD.</p><p><b>RESULTS: </b>Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs11444867 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16).</p><p><b>CONCLUSIONS: </b>The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.</p> |
| DOI | 10.2337/dc23-2274 |
| Alternate Journal | Diabetes Care |
| PubMed ID | 38652672 |
| Grant List | P30-DK063491 / DK / NIDDK NIH HHS / United States U01HG011723 / HG / NHGRI NIH HHS / United States UL1TR001420 / TR / NCATS NIH HHS / United States |
ePub date:
24/04