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A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.
Thursday,2024-04-04 11:35 America/Los_Angeles — ecterry
| Title | A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Nagarajan, P, Winkler, TW, Bentley, AR, Miller, CL, Kraja, AT, Schwander, K, Lee, S, Wang, W, Brown, MR, Morrison, JL, Giri, A, O'Connell, JR, Bartz, TM, Fuentes, Lde Las, Gudmundsdottir, V, Guo, X, Harris, SE, Huang, Z, Kals, M, Kho, M, Lefevre, C, Luan, J'an, Lyytikäinen, L-P, Mangino, M, Milaneschi, Y, Palmer, ND, Rao, V, Rauramaa, R, Shen, B, Stadler, S, Sun, Q, Tang, J, Thériault, S, van der Graaf, A, van der Most, PJ, Wang, Y, Weiss, S, Westerman, KE, Yang, Q, Yasuharu, T, Zhao, W, Zhu, W, Altschul, D, Ansari, MAbu Yusuf, Anugu, P, Argoty-Pantoja, AD, Arzt, M, Aschard, H, Attia, JR, Bazzanno, L, Breyer, MA, Brody, JA, Cade, BE, Chen, H-H, Chen, Y-DIda, Chen, Z, de Vries, PS, Dimitrov, LM, Do, A, Du, J, Dupont, CT, Edwards, TL, Evans, MK, Faquih, T, Felix, SB, Fisher-Hoch, SP, Floyd, JS, Graff, M, Gu, C, Gu, D, Hairston, KG, Hanley, AJ, Heid, IM, Heikkinen, S, Highland, HM, Hood, MM, Kähönen, M, Karvonen-Gutierrez, CA, Kawaguchi, T, Kazuya, S, Kelly, TN, Komulainen, P, Levy, D, Lin, HJ, Liu, PY, Marques-Vidal, P, McCormick, JB, Mei, H, Meigs, JB, Menni, C, Nam, K, Nolte, IM, Pacheco, NL, Petty, LE, Polikowsky, HG, Province, MA, Psaty, BM, Raffield, LM, Raitakari, OT, Rich, SS, Riha, RL, Risch, L, Risch, M, Ruiz-Narvaez, EA, Scott, RJ, Sitlani, CM, Smith, JA, Sofer, T, Teder-Laving, M, Völker, U, Vollenweider, P, Wang, G, van Dijk, KW, Wilson, OD, Xia, R, Yao, J, Young, KL, Zhang, R, Zhu, X, Below, JE, Böger, CA, Conen, D, Cox, SR, Dörr, M, Feitosa, MF, Fox, ER, Franceschini, N, Gharib, SA, Gudnason, V, Harlow, SD, He, J, Holliday, EG, Kutalik, Z, Lakka, TA, Lawlor, DA, Lee, S, Lehtimäki, T, Li, C, Liu, C-T, Mägi, R, Matsuda, F, Morrison, AC, Penninx, BWjh, Peyser, PA, Rotter, JI, Snieder, H, Spector, TD, Wagenknecht, LE, Wareham, NJ, Zonderman, AB, North, KE, Fornage, M, Hung, AM, Manning, AK, Gauderman, J, Chen, H, Munroe, PB, Rao, DC, van Heemst, D, Redline, S, Noordam, R, Wang, H |
| Corporate/Institutional Authors | Million Veteran Program |
| Journal | medRxiv |
| Date Published | 2024 Mar 08 |
| Abstract | <p>Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management.</p> |
| DOI | 10.1101/2024.03.07.24303870 |
| Alternate Journal | medRxiv |
| PubMed ID | 38496537 |
| PubMed Central ID | PMC10942520 |
| Grant List | I01 CX001897 / CX / CSRD VA / United States R01 HL118305 / HL / NHLBI NIH HHS / United States R01 HL156991 / HL / NHLBI NIH HHS / United States |
ePub date:
24/03