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Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
Thursday,2024-02-01 21:24 America/Los_Angeles — ecterry
| Title | Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Guirette, M, Lan, J, McKeown, N, Brown, MR, Chen, H, de Vries, PS, Kim, H, Rebholz, CM, Morrison, AC, Bartz, TM, Fretts, AM, Guo, X, Lemaitre, RN, Liu, C-T, Noordam, R, de Mutsert, R, Rosendaal, FR, Wang, CA, Beilin, L, Mori, TA, Oddy, WH, Pennell, CE, Chai, JFang, Whitton, C, van Dam, RM, Liu, J, Tai, SE, Sim, X, Neuhouser, ML, Kooperberg, C, Tinker, L, Franceschini, N, Huan, T, Winkler, TW, Bentley, AR, W Gauderman, J, Heerkens, L, Tanaka, T, van Rooij, J, Munroe, PB, Warren, HR, Voortman, T, Chen, H, Rao, DC, Levy, D, Ma, J |
| Journal | medRxiv |
| Date Published | 2023 Nov 11 |
| Abstract | <p><b>OBJECTIVE: </b>We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).</p><p><b>METHODS: </b>We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses.</p><p><b>RESULTS: </b>We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with -expression quantitative trait loci (eQTL) variants (P = 4e-273) and -DNA methylation quantitative trait loci (mQTL) variants (P = 1e-300). While the closest gene for rs117878928 is , the highest narrow sense heritability accounted by SNPs potentially interacting with the DASH diet score in this locus was for gene at 15q25.1.</p><p><b>CONCLUSION: </b>We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.</p> |
| DOI | 10.1101/2023.11.10.23298402 |
| Alternate Journal | medRxiv |
| PubMed ID | 37986948 |
| PubMed Central ID | PMC10659476 |
ePub date:
23/11