You are here
Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts.
Wednesday,2023-08-23 18:12 America/Los_Angeles — ecterry
| Title | Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Yang, C, Veenstra, J, Bartz, T, Pahl, M, Hallmark, B, Chen, Y-DI, Westra, J, Steffen, L, Brown, C, Siscovick, D, Tsai, M, Wood, A, Rich, S, Smith, C, O'Connor, T, Mozaffarian, D, Grant, S, Chilton, F, Tintle, N, Lemaitre, R, Manichaikul, A |
| Journal | Res Sq |
| Date Published | 2023 Feb 24 |
| Abstract | <p>Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of < 5 x 10 , we confirmed association of the signal and found evidence of two additional signals (in and ) within 200 kb of the originally reported signal. Outside of the region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including , , and spanning a > 9 Mb region on chromosome 11 (57.5Mb ~ 67.1Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations.</p> |
| DOI | 10.21203/rs.3.rs-2073736/v1 |
| Alternate Journal | Res Sq |
| PubMed ID | 36865120 |
| PubMed Central ID | PMC9980229 |
ePub date:
23/02