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-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies
Wednesday,2023-08-23 17:27 America/Los_Angeles — ecterry
| Title | -3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Del Gobbo, LC, Imamura, F, Aslibekyan, S, Marklund, M, Virtanen, JK, Wennberg, M, Yakoob, MY, Chiuve, SE, L. Cruz, D, Frazier-Wood, AC, Fretts, AM, Guallar, E, Matsumoto, C, Prem, K, Tanaka, T, Wu, JH, Zhou, X, Helmer, C, Ingelsson, E, Yuan, JM, Barberger-Gateau, P, Campos, H, Chaves, PH, é, L, Giles, GG, mez-Aracena, J, Hodge, AM, Hu, FB, Jansson, JH, Johansson, I, Khaw, KT, Koh, WP, Lemaitre, RN, Lind, L, Luben, RN, Rimm, EB, rus, U, Samieri, C, Franks, PW, Siscovick, DS, Stampfer, M, Steffen, LM, Steffen, BT, Tsai, MY, van Dam, RM, Voutilainen, S, Willett, WC, Woodward, M, Mozaffarian, D |
| Journal | JAMA Intern Med |
| Volume | 176 |
| Pagination | 1155–1166 |
| Date Published | Aug |
| Abstract | -3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers.\ -3) for incident CHD.\ A global consortium of 19 studies identified by November 2014.\ -3 biomarkers and ascertained CHD.\ -6 levels, and FADS desaturase genes.\ Incident total CHD, fatal CHD, and nonfatal myocardial infarction (MI).\ -3 biomarkers ALA, DPA, and DHA were associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95% CI, 0.84-0.98) for ALA, 0.90 (95% CI, 0.85-0.96) for DPA, and 0.90 (95% CI, 0.84-0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95% CI, 0.90-0.99), ALA (RR, 1.00; 95% CI, 0.95-1.05), EPA (RR, 0.94; 95% CI, 0.87-1.02), and DHA (RR, 0.95; 95% CI, 0.91-1.00) were not. Significant associations with nonfatal MI were not evident. Associations appeared generally stronger in phospholipids and total plasma. Restricted cubic splines did not identify evidence of nonlinearity in dose responses.\ -3 fatty acids are associated with a modestly lower incidence of fatal CHD. |
ePub date:
16/08