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Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Carmichael, OT, Kuller, LH, Lopez, OL, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Aizenstein, HJ, Meltzer, CC, Liu, Y, Toga, AW, Becker, JT |
| Journal | Alzheimer Dis Assoc Disord |
| Volume | 21 |
| Issue | 1 |
| Pagination | 14-24 |
| Date Published | 2007 Jan-Mar |
| ISSN | 0893-0341 |
| Keywords | Aged, Aged, 80 and over, Case-Control Studies, Cerebral Ventricles, Cognition Disorders, Dementia, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Risk Factors, Severity of Illness Index, Time Factors |
| Abstract | <p>Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive impairment (MCI), and dementia is not well understood. Furthermore, the effects of cardiovascular risk factors on rate of ventricular expansion are unclear. We used a fully automated segmentation technique to measure change rate in lateral ventricle-to-brain ratio (VBR) on 145 longitudinal pairs of magnetic resonance images of subjects in the Cardiovascular Health Study Cognition Study from the Pittsburgh Center. A multivariate model analyzed VBR change rate, accounting for dementia statuses at both imaging times (normal, MCI, or dementia), age, sex, education, race, magnetic resonance-defined infarcts, Center for Epidemiology Studies Depression Scale, baseline ventricular volume, and cardiovascular risk factors. VBR change was faster in subjects who were demented or transitioned from MCI to dementia, compared with subjects normal at both images and subjects who transitioned from normal to MCI or dementia. Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes.</p> |
| DOI | 10.1097/WAD.0b013e318032d2b1 |
| Alternate Journal | Alzheimer Dis Assoc Disord |
| PubMed ID | 17334268 |
| PubMed Central ID | PMC2879163 |
| Grant List | N01 HC 85085 / HC / NHLBI NIH HHS / United States N01 HC 85083 / HC / NHLBI NIH HHS / United States R21 EB001561 / EB / NIBIB NIH HHS / United States T32 NS007391 / NS / NINDS NIH HHS / United States P41 RR013642-070061 / RR / NCRR NIH HHS / United States R01 AG020098-07 / AG / NIA NIH HHS / United States U01 HL 080295 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States AG 05133 / AG / NIA NIH HHS / United States R21 RR019771 / RR / NCRR NIH HHS / United States MH 064625 / MH / NIMH NIH HHS / United States MH 01077 / MH / NIMH NIH HHS / United States RR 019771 / RR / NCRR NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01 HC 85084 / HC / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States K24 MH064625 / MH / NIMH NIH HHS / United States N01 HC 85086 / HC / NHLBI NIH HHS / United States N01 HC 35129 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01 HC 85081 / HC / NHLBI NIH HHS / United States N01 HC 85079 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States AG 15928 / AG / NIA NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States N01 HC 55222 / HC / NHLBI NIH HHS / United States EB 001561 / EB / NIBIB NIH HHS / United States AG 20098 / AG / NIA NIH HHS / United States T32 NS007391-06 / NS / NINDS NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States P41 RR013642 / RR / NCRR NIH HHS / United States N01 HC 85080 / HC / NHLBI NIH HHS / United States U54 RR021813 / RR / NCRR NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States R21 DA015900 / DA / NIDA NIH HHS / United States N01 HC 15103 / HC / NHLBI NIH HHS / United States NS 07391 / NS / NINDS NIH HHS / United States AG 016570 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC 85082 / HC / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States RR 021813 / RR / NCRR NIH HHS / United States DA 015900-01 / DA / NIDA NIH HHS / United States |