You are here
{Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors
Saturday,2023-06-17 14:03 America/Los_Angeles — ecterry
| Title | {Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Levine, DA, Chen, B, Galecki, AT, Gross, AL, o, EM, Whitney, RT, Ploutz-Snyder, RJ, Giordani, BJ, Sussman, JB, Burke, JF, Lazar, RM, Howard, VJ, Aparicio, HJ, Beiser, AS, Elkind, MSV, Gottesman, RF, Koton, S, Pendlebury, ST, Sharma, A, Springer, MV, Seshadri, S, Romero, JR, Hayward, RA |
| Journal | JAMA Netw Open |
| Volume | 6 |
| Pagination | e2313879 |
| Date Published | May |
| Abstract | Incident stroke is associated with accelerated cognitive decline. Whether poststroke vascular risk factor levels are associated with faster cognitive decline is uncertain.\ To evaluate associations of poststroke systolic blood pressure (SBP), glucose, and low-density lipoprotein (LDL) cholesterol levels with cognitive decline.\ Individual participant data meta-analysis of 4 US cohort studies (conducted 1971-2019). Linear mixed-effects models estimated changes in cognition after incident stroke. Median (IQR) follow-up was 4.7 (2.6-7.9) years. Analysis began August 2021 and was completed March 2023.\ Time-dependent cumulative mean poststroke SBP, glucose, and LDL cholesterol levels.\ The primary outcome was change in global cognition. Secondary outcomes were change in executive function and memory. Outcomes were standardized as t scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1-SD difference in cognition.\ .002) but not executive function or memory declines.\ In this cohort study, higher poststroke glucose levels were associated with faster global cognitive decline. We found no evidence that poststroke LDL cholesterol and SBP levels were associated with cognitive decline. |
ePub date:
23/05