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Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Tikellis, G, Sun, C, Gorin, MB, Klein, R, Klein, BEK, Larsen, EKMarino, Siscovick, DS, Hubbard, LD, Wong, TY |
| Journal | Arch Ophthalmol |
| Volume | 125 |
| Issue | 1 |
| Pagination | 68-73 |
| Date Published | 2007 Jan |
| ISSN | 0003-9950 |
| Keywords | African Americans, Aged, Aged, 80 and over, Alleles, Apolipoprotein E2, Apolipoprotein E3, Apolipoprotein E4, Cardiovascular Diseases, European Continental Ancestry Group, Female, Genotype, Humans, Macular Degeneration, Male, Odds Ratio, Polymorphism, Genetic, Risk Factors |
| Abstract | <p><b>OBJECTIVE: </b>To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population.</p><p><b>METHODS: </b>Two thousand one hundred seventy persons 65 years and older sampled from 4 US communities had ARM signs assessed from retinal photographs using a modified Wisconsin Age-Related Maculopathy Grading System. DNA extracted from blood samples was analyzed for common APOE alleles.</p><p><b>RESULTS: </b>After controlling for age, sex, cigarette smoking, and other factors, white participants carrying the epsilon2 allele had an increased risk of late ARM (odds ratio, 2.53 [95% confidence interval, 1.08-5.90]) while carriers of the epsilon4 allele had a lower risk of late ARM (odds ratio, 0.69 [95% confidence interval, 0.19-2.50]). There were too few late ARM cases in African American individuals for analysis.</p><p><b>CONCLUSION: </b>APOE polymorphism is associated with late ARM in older white persons 65 years and older. Consistent with previous studies, the APOE epsilon2 allele is associated with a significant increased risk of late ARM development, whereas the epsilon4 allele may confer some protection.</p> |
| DOI | 10.1001/archopht.125.1.68 |
| Alternate Journal | Arch Ophthalmol |
| PubMed ID | 17210854 |
| Grant List | HC-97-06 / HC / NHLBI NIH HHS / United States R21-HL077166 / HL / NHLBI NIH HHS / United States |