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Genome-wide analyses identify as a susceptibility locus for premature atrial contraction frequency.
Monday,2023-04-03 16:57 America/Los_Angeles — ecterry
| Title | Genome-wide analyses identify as a susceptibility locus for premature atrial contraction frequency. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Thériault, S, Imboden, M, Biggs, ML, Austin, TR, Aeschbacher, S, Schaffner, E, Brody, JA, Bartz, TM, Risch, M, Grossmann, K, Lin, HJ, Soliman, EZ, Post, WS, Risch, L, Krieger, JE, Pereira, AC, Heckbert, SR, Sotoodehnia, N, Probst-Hensch, NM, Conen, D |
| Journal | iScience |
| Volume | 25 |
| Issue | 10 |
| Pagination | 105210 |
| Date Published | 2022 Oct 21 |
| ISSN | 2589-0042 |
| Abstract | <p>Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a genome-wide significant locus at the gene. The lead variant, rs7373862, located in an intron of , was associated with an increase of 0.12 [95% CI 0.08-0.16] standard deviations of the normalized PAC frequency per risk allele. Among genetic variants previously associated with AF, there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 × 10). However, several AF risk loci, including , were not associated with PAC frequency. These findings suggest the existence of both shared and distinct genetic mechanisms for PAC frequency and AF.</p> |
| DOI | 10.1016/j.isci.2022.105210 |
| Alternate Journal | iScience |
| PubMed ID | 36267918 |
| PubMed Central ID | PMC9576575 |
| Grant List | R01 HL105756 / HL / NHLBI NIH HHS / United States |
ePub date:
22/09