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Circulating differentiated and senescent lymphocyte subsets and incident diabetes risk in older adults: The Cardiovascular Health Study.
Monday,2023-01-30 11:54 America/Los_Angeles — ecterry
| Title | Circulating differentiated and senescent lymphocyte subsets and incident diabetes risk in older adults: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Olson, NC, Doyle, MF, Bůzková, P, Huber, SA, de Boer, IH, Sitlani, CM, Tracy, RP, Psaty, BM, Mukamal, KJ, Delaney, JA |
| Journal | Endocrinol Diabetes Metab |
| Volume | 6 |
| Issue | 1 |
| Pagination | e384 |
| Date Published | 2023 Jan |
| ISSN | 2398-9238 |
| Keywords | CD28 Antigens, CD8-Positive T-Lymphocytes, Cellular Senescence, Diabetes Mellitus, Leukocytes, Mononuclear, Lymphocyte Subsets |
| Abstract | <p><b>INTRODUCTION: </b>Cellular senescence is a feature of aging implicated in the pathophysiology of diabetes mellitus (DM). Whether senescent lymphocytes are associated with the future occurrence of DM is uncertain.</p><p><b>METHODS: </b>We used cryopreserved peripheral blood mononuclear cells collected from 1860 Cardiovascular Health Study participants (average age 80.2 years) and flow cytometry immunophenotyping to evaluate the longitudinal relationships of naive (CD45RA ), memory (CD45RO ), senescent (CD28 ), and T effector memory RA (TEMRA) (CD28 CD57 CD45RA ) CD4 and CD8 T cells, and memory B cells (CD19 CD27 ), with the risk of incident DM. In exploratory analyses we evaluated the relationships of 13 additional innate lymphocyte and CD4 and CD8 subsets with incident DM risk.</p><p><b>RESULTS: </b>Over a median follow-up time of 8.9 years, 155 cases of incident DM occurred. In Cox models adjusted for demographic variables (age, sex, race, study site and flow cytometry analytical batch) or diabetes risk factors (demographic variables plus education, body mass index, smoking status, alcohol use, systolic blood pressure, hypertension medication use and physical activity), no significant associations were observed for any CD4 , CD8 or CD19 cell phenotypes with incident DM.</p><p><b>CONCLUSIONS: </b>These results suggest the frequencies of naive, memory and senescent T cells and memory B cells are not strongly associated with incident DM risk in older adults.</p> |
| DOI | 10.1002/edm2.384 |
| Alternate Journal | Endocrinol Diabetes Metab |
| PubMed ID | 36333945 |
| PubMed Central ID | PMC9836256 |
| Grant List | U01HL080295 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States U01HL080295 / AG / NIA NIH HHS / United States HHSN268201800001C / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States R00HL129045 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States R01HL135625 / HL / NHLBI NIH HHS / United States R01 HL120854 / HL / NHLBI NIH HHS / United States R01 HL135625 / HL / NHLBI NIH HHS / United States R01HL120854 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R00HL129045 / HL / NHLBI NIH HHS / United States R01HL120854 / HL / NHLBI NIH HHS / United States R01HL135625 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States HHSN268201800001C / AG / NIA NIH HHS / United States U01HL080295 / AG / NIA NIH HHS / United States |
ePub date:
23/01