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Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Carmichael, OT, Kuller, LH, Lopez, OL, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Aizenstein, HJ, Meltzer, CC, Liu, Y, Toga, AW, Becker, JT |
| Journal | Neurobiol Aging |
| Volume | 28 |
| Issue | 9 |
| Pagination | 1316-21 |
| Date Published | 2007 Sep |
| ISSN | 1558-1497 |
| Keywords | Aged, Analysis of Variance, Cardiovascular Diseases, Cerebral Ventricles, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Reference Values, Retrospective Studies, Sex Factors, Time Factors |
| Abstract | <p>Interactions between prevalent late-life medical conditions and expansion of the cerebral ventricles are not well understood. Thirty elderly subjects received three magnetic resonance (MR) scans each, in 1997-1999, 2002-2004, and 2003-2005. A linear expansion model of MR-measured lateral ventricle volume was estimated for each subject by fitting a line to a plot of their 1997-1999 and 2002-2004 volumes as a function of time. Acceleration in ventricular expansion was defined as the deviation between the 2003-2005 volumes measured from MR and the 2003-2005 volumes predicted by the linear expansion model. Ventricular acceleration was analyzed in a multivariate model with age, race, history of heart disease, diabetes, and hypertension as fixed effects. Ventricular acceleration was significantly higher in non-whites, diabetics, and those without heart disease (p<0.05). Ventricular acceleration was higher in subjects with a history of hypertension, but the difference was not statistically significant (p=0.08). Acceleration of ventricular expansion in the elderly may be related to demographic and cardiovascular factors.</p> |
| DOI | 10.1016/j.neurobiolaging.2006.06.016 |
| Alternate Journal | Neurobiol Aging |
| PubMed ID | 16875759 |
| PubMed Central ID | PMC2877585 |
| Grant List | R21 EB001561 / EB / NIBIB NIH HHS / United States T32 NS007391 / NS / NINDS NIH HHS / United States P41 RR013642-070061 / RR / NCRR NIH HHS / United States R01 AG020098-07 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States AG016570 / AG / NIA NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R21 RR019771 / RR / NCRR NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States MH01077 / MH / NIMH NIH HHS / United States K24 MH064625 / MH / NIMH NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States RR019771 / RR / NCRR NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States AG05133 / AG / NIA NIH HHS / United States T32 NS007391-06 / NS / NINDS NIH HHS / United States DA015900-01 / DA / NIDA NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States P41 RR013642 / RR / NCRR NIH HHS / United States U54 RR021813 / RR / NCRR NIH HHS / United States RR021813 / RR / NCRR NIH HHS / United States EB001561 / EB / NIBIB NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States R21 DA015900 / DA / NIDA NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States AG20098 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States MH064625 / MH / NIMH NIH HHS / United States NS07391 / NS / NINDS NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States |