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Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts.
Friday,2022-04-15 16:09 America/Los_Angeles — ecterry
| Title | Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Zhang, L, Bartz, TM, Santanasto, A, Djoussé, L, Mukamal, KJ, Forman, DE, Hirsch, CH, Newman, AB, Gottdiener, JS, Kizer, JR |
| Journal | J Am Heart Assoc |
| Volume | 11 |
| Issue | 1 |
| Pagination | e023707 |
| Date Published | 2022 01 04 |
| ISSN | 2047-9980 |
| Keywords | Absorptiometry, Photon, Aged, Aging, Body Composition, Body Mass Index, Heart Failure, Humans, Muscle, Skeletal, Prospective Studies |
| Abstract | <p>Background Aging is associated with central fat redistribution and skeletal muscle decline, yet the relationships of tissue compartments with heart failure (HF) remain incompletely characterized. We assessed the contribution of body composition to incident HF in elders. Methods and Results Participants from 2 older cohorts who completed dual-energy X-ray absorptiometry (DEXA) and, in one cohort, computed tomography were included. We evaluated associations with incident HF for DEXA principal components (PCs) and total lean, appendicular lean, total fat and trunk fat mass; and for computed tomography measures of abdominal visceral and subcutaneous fat, thigh muscle, intermuscular fat area and thigh muscle density. DEXA analysis included 3621, and computed tomography analysis 2332 participants. During median follow-up of 11.8 years, 927 participants developed HF. DEXA principal components showed no relationship with HF. After adjustment for height, weight, and cardiovascular risk factors, total lean mass was near significantly associated with higher HF (hazard ratio [HR], 1.25 per SD [1.00-1.56]), whereas total fat mass and thigh muscle density were significantly related to lower HF (HR, 0.82 [0.68-0.99] and HR, 0.87 [0.78-0.97], respectively). Patterns were similar for HF subtypes. The relationships with HF for total lean and fat mass were attenuated after adjusting for intercurrent atrial fibrillation or excluding high natriuretic peptide levels. Conclusions Total lean mass was positively associated, while total fat mass and thigh muscle density were inversely associated, with incident HF. These findings highlight the limitations of DEXA for assessment of HF risk in elders and support the preeminence of computed tomography-measured skeletal muscle quality over mass as a determinant of HF incidence.</p> |
| DOI | 10.1161/JAHA.121.023707 |
| Alternate Journal | J Am Heart Assoc |
| PubMed ID | 34927442 |
| Grant List | K01 AG057726 / AG / NIA NIH HHS / United States R01 AG053325 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01 AG062101 / AG / NIA NIH HHS / United States N01 AG062103 / AG / NIA NIH HHS / United States N01 AG062106 / AG / NIA NIH HHS / United States R01 AG028050 / AG / NIA NIH HHS / United States R01 NR012459 / NR / NINR NIH HHS / United States K24 HL135413 / HL / NHLBI NIH HHS / United States |
ePub date:
22/01