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Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS).
Friday,2022-03-04 21:18 America/Los_Angeles — ecterry
| Title | Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS). |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Sillah, A, Watson, NF, Peters, U, Biggs, ML, F Nieto, J, Li, CI, Gozal, D, Thornton, T, Barrie, S, Phipps, AI |
| Journal | Cancer Epidemiol |
| Volume | 76 |
| Pagination | 102057 |
| Date Published | 2022 Feb |
| ISSN | 1877-783X |
| Abstract | <p><b>BACKGROUND: </b>Sleep problems (SP) can indicate underlying sleep disorders, such as obstructive sleep apnea, which may adversely impact cancer risk and mortality.</p><p><b>METHODS: </b>We assessed the association of baseline and longitudinal sleep apnea and insomnia symptoms with incident cancer (N = 3930) and cancer mortality (N = 4580) in the Cardiovascular Health Study. We used Cox proportional hazards regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) to evaluate the associations.</p><p><b>RESULTS: </b>Overall, 885 incident cancers and 804 cancer deaths were identified over a median follow-up of 12 and 14 years, respectively. Compared to participants who reported no sleep apnea symptoms, the risk of incident cancer was inversely associated [(HR (95%CI)] with snoring [0.84 (0.71, 0.99)]. We noted an elevated prostate cancer incidence for apnea [2.34 (1.32, 4.15)] and snoring [1.69 (1.11, 2.57)]. We also noted an elevated HR for lymphatic or hematopoietic cancers [daytime sleepiness: 1.81 (1.06, 3.08)]. We found an inverse relationship for cancer mortality with respect to snoring [0.73 (0.62, 0.8)] and apnea [(0.69 (0.51, 0.94))]. We noted a significant inverse relationship between difficulty falling asleep and colorectal cancer death [0.32 (0.15, 0.69)] and snoring with lung cancer death [0.56 (0.35, 0.89)].</p><p><b>CONCLUSIONS: </b>The relationship between SP and cancer risk and mortality was heterogeneous. Larger prospective studies addressing more cancer sites, molecular type-specific associations, and better longitudinal SP assessments are needed for improved delineation of SP-cancer risk dyad.</p> |
| DOI | 10.1016/j.canep.2021.102057 |
| Alternate Journal | Cancer Epidemiol |
| PubMed ID | 34798387 |
| PubMed Central ID | PMC8792277 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States T32 CA094880 / CA / NCI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
21/11