You are here
Association of mitochondrial DNA copy number with cardiometabolic diseases.
Friday,2022-03-04 14:24 America/Los_Angeles — ecterry
| Title | Association of mitochondrial DNA copy number with cardiometabolic diseases. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Liu, X, Longchamps, RJ, Wiggins, KL, Raffield, LM, Bielak, LF, Zhao, W, Pitsillides, A, Blackwell, TW, Yao, J, Guo, X, Kurniansyah, N, Thyagarajan, B, Pankratz, N, Rich, SS, Taylor, KD, Peyser, PA, Heckbert, SR, Seshadri, S, Cupples, AL, Boerwinkle, E, Grove, ML, Larson, NB, Smith, JA, Vasan, RS, Sofer, T, Fitzpatrick, AL, Fornage, M, Ding, J, Correa, A, Abecasis, G, Psaty, BM, Wilson, JG, Levy, D, Rotter, JI, Bis, JC, Satizabal, CL, Arking, DE, Liu, C |
| Corporate/Institutional Authors | TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium |
| Journal | Cell Genom |
| Volume | 1 |
| Issue | 1 |
| Date Published | 2021 Oct 13 |
| ISSN | 2666-979X |
| Abstract | <p>Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: among younger participants (<65 years of age), each additional 10 years of age was associated with 0.03 standard deviation (s.d.) higher level of mtDNA CN ( = 0.0014) versus a 0.14 s.d. lower level of mtDNA CN ( = 1.82 × 10) among older participants (≥65 years). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity ( = 5.6 × 10), hypertension ( = 2.8 × 10), diabetes ( = 3.6 × 10), and hyperlipidemia ( = 6.3 × 10). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases.</p> |
| DOI | 10.1016/j.xgen.2021.100006 |
| Alternate Journal | Cell Genom |
| PubMed ID | 35036986 |
| PubMed Central ID | PMC8758111 |
| Grant List | R01 AG059727 / AG / NIA NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States |
ePub date:
21/10