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Ventricular volume and dementia progression in the Cardiovascular Health Study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Ventricular volume and dementia progression in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Carmichael, OT, Kuller, LH, Lopez, OL, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Aizenstein, HJ, Meltzer, CCidis, Liu, Y, Toga, AW, Becker, JT |
| Journal | Neurobiol Aging |
| Volume | 28 |
| Issue | 3 |
| Pagination | 389-97 |
| Date Published | 2007 Mar |
| ISSN | 1558-1497 |
| Keywords | Aged, Aged, 80 and over, Aging, Cognition Disorders, Cross-Sectional Studies, Dementia, Disease Progression, Female, Follow-Up Studies, Humans, Lateral Ventricles, Linear Models, Magnetic Resonance Imaging, Male, Predictive Value of Tests, Prospective Studies, Retrospective Studies, Time Factors |
| Abstract | <p>Elevated cerebral ventricular volume may be associated with dementia risk and progression. A fully-automated technique that agreed highly with radiological readings was used to estimate lateral ventricle volume on MR scans done at baseline in 1997-99 of 377 subjects in the Cardiovascular Health Study (CHS) from the Pittsburgh Center. 327 subjects were normal or diagnosed with mild cognitive impairment (MCI) at baseline and were evaluated 4 years later. Baseline ventricular volume was analyzed in multivariate models with age, gender, education level, presence and incidence of cerebral infarcts, and dementia category (normal, MCI, or dementia) at baseline and follow-up as fixed effects. Ventricular volume at baseline was significantly higher among subjects normal at baseline and demented 4 years later. Age, gender, education level, and dementia progression were significant factors affecting ventricular volume. Ventricular volume was higher in dementia compared to MCI, higher in MCI compared to controls, and higher in Possible-Alzheimer's-disease (AD) dementia compared to Probable-AD. Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology.</p> |
| DOI | 10.1016/j.neurobiolaging.2006.01.006 |
| Alternate Journal | Neurobiol Aging |
| PubMed ID | 16504345 |
| PubMed Central ID | PMC2866509 |
| Grant List | R21 EB001561 / EB / NIBIB NIH HHS / United States T32 NS007391 / NS / NINDS NIH HHS / United States P41 RR013642-070061 / RR / NCRR NIH HHS / United States R01 AG020098-07 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States AG016570 / AG / NIA NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States R21 RR019771 / RR / NCRR NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States MH01077 / MH / NIMH NIH HHS / United States K24 MH064625 / MH / NIMH NIH HHS / United States RR019771 / RR / NCRR NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States AG05133 / AG / NIA NIH HHS / United States T32 NS007391-06 / NS / NINDS NIH HHS / United States DA015900-01 / DA / NIDA NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States P41 RR013642 / RR / NCRR NIH HHS / United States U54 RR021813 / RR / NCRR NIH HHS / United States RR021813 / RR / NCRR NIH HHS / United States EB001561 / EB / NIBIB NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States R21 DA015900 / DA / NIDA NIH HHS / United States P50 CA128301-029001 / CA / NCI NIH HHS / United States AG20098 / AG / NIA NIH HHS / United States MH064625 / MH / NIMH NIH HHS / United States NS07391 / NS / NINDS NIH HHS / United States |