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Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study.
Monday,2021-08-23 14:38 America/Los_Angeles — ecterry
| Title | Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Andrews, RM, Shpitser, I, Lopez, O, Longstreth, WT, Chaves, PHM, Kuller, L, Carlson, MC |
| Journal | J R Stat Soc Ser A Stat Soc |
| Volume | 183 |
| Issue | 4 |
| Pagination | 1705-1726 |
| Date Published | 2020 Oct |
| ISSN | 0964-1998 |
| Abstract | <p>The paper examines whether leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascular-related brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.</p> |
| DOI | 10.1111/rssa.12570 |
| Alternate Journal | J R Stat Soc Ser A Stat Soc |
| PubMed ID | 34321718 |
| PubMed Central ID | PMC8314961 |
| Grant List | R01 AI127271 / AI / NIAID NIH HHS / United States |
ePub date:
20/10