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Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Jenny, NS, Arnold, AM, Kuller, LH, Sharrett, AR, Fried, LP, Psaty, BM, Tracy, RP |
| Journal | J Thromb Haemost |
| Volume | 4 |
| Issue | 1 |
| Pagination | 107-13 |
| Date Published | 2006 Jan |
| ISSN | 1538-7933 |
| Keywords | Aged, Aged, 80 and over, Angina Pectoris, Biomarkers, Cardiovascular Diseases, Female, Humans, Incidence, Intercellular Adhesion Molecule-1, Male, Mortality, Myocardial Infarction, Regression Analysis, Risk Factors, Sex Factors, Solubility, Stroke |
| Abstract | <p><b>BACKGROUND: </b>Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression.</p><p><b>OBJECTIVES: </b>We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study.</p><p><b>METHODS: </b>Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up.</p><p><b>RESULTS: </b>sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events.</p><p><b>CONCLUSIONS: </b>While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.</p> |
| DOI | 10.1111/j.1538-7836.2005.01678.x |
| Alternate Journal | J Thromb Haemost |
| PubMed ID | 16409459 |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |