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Cerebral Blood Flow Predicts Conversion of Mild Cognitive Impairment into Alzheimer's Disease and Cognitive Decline: An Arterial Spin Labeling Follow-up Study.
Tuesday,2021-07-20 12:53 America/Los_Angeles — ecterry
| Title | Cerebral Blood Flow Predicts Conversion of Mild Cognitive Impairment into Alzheimer's Disease and Cognitive Decline: An Arterial Spin Labeling Follow-up Study. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Duan, W, Zhou, GD, Balachandrasekaran, A, Bhumkar, AB, Boraste, PB, Becker, JT, Kuller, LH, Lopez, OL, H Gach, M, Dai, W |
| Journal | J Alzheimers Dis |
| Volume | 82 |
| Issue | 1 |
| Pagination | 293-305 |
| Date Published | 2021 |
| ISSN | 1875-8908 |
| Abstract | <p><b>BACKGROUND: </b>This is the first longitudinal study to assess regional cerebral blood flow (rCBF) changes during the progression from normal control (NC) through mild cognitive impairment (MCI) and Alzheimer's disease (AD).</p><p><b>OBJECTIVE: </b>We aim to determine if perfusion MRI biomarkers, derived from our prior cross-sectional study, can predict the onset and cognitive decline of AD.</p><p><b>METHODS: </b>Perfusion MRIs using arterial spin labeling (ASL) were acquired in 15 stable-NC, 14 NC-to-MCI, 16 stable-MCI, and 18 MCI/AD-to-AD participants from the Cardiovascular Health Study (CHS) cognition study. Group comparisons, predictions of AD conversion and time to conversion, and Modified Mini-Mental State Examination (3MSE) from rCBF were performed.</p><p><b>RESULTS: </b>Compared to the stable-NC group: 1) the stable-MCI group exhibited rCBF decreases in the right temporoparietal (p = 0.00010) and right inferior frontal and insula (p = 0.0094) regions; and 2) the MCI/AD-to-AD group exhibited rCBF decreases in the bilateral temporoparietal regions (p = 0.00062 and 0.0035). Compared to the NC-to-MCI group, the stable-MCI group exhibited a rCBF decrease in the right hippocampus region (p = 0.0053). The baseline rCBF values in the posterior cingulate cortex (PCC) (p = 0.0043), bilateral superior medial frontal regions (BSMF) (p = 0.012), and left inferior frontal (p = 0.010) regions predicted the 3MSE scores for all the participants at follow-up. The baseline rCBF in the PCC and BSMF regions predicted the conversion and time to conversion from MCI to AD (p < 0.05; not significant after multiple corrections).</p><p><b>CONCLUSION: </b>We demonstrated the feasibility of ASL in detecting rCBF changes in the typical AD-affected regions and the predictive value of baseline rCBF on AD conversion and cognitive decline.</p> |
| DOI | 10.3233/JAD-210199 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 34024834 |
ePub date:
21/05