You are here
Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study.
Monday,2021-01-25 17:00 America/Los_Angeles — ecterry
| Title | Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Rohmann, JL, Longstreth, WT, Cushman, M, Fitzpatrick, AL, Heckbert, SR, Rice, K, Rosendaal, FR, Sitlani, CM, Psaty, BM, Siegerink, B |
| Journal | PLoS One |
| Volume | 15 |
| Issue | 11 |
| Pagination | e0242062 |
| Date Published | 2020 |
| ISSN | 1932-6203 |
| Keywords | Aged, Blood Coagulation, Cognition, Cross-Sectional Studies, Factor VIII, Female, Humans, Logistic Models, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status and Dementia Tests, Up-Regulation, White Matter |
| Abstract | <p><b>OBJECTIVE: </b>To investigate the relationship between high FVIII clotting activity (FVIII:C), MRI-defined white matter hyperintensities (WMH) and cognitive function over time.</p><p><b>METHODS: </b>Data from the population-based Cardiovascular Health Study (n = 5,888, aged ≥65) were used. FVIII:C was measured in blood samples taken at baseline. WMH burden was assessed on two cranial MRI scans taken roughly 5 years apart. Cognitive function was assessed annually using the Modified Mini-Mental State Examination (3MSE) and Digit Symbol Substitution Test (DSST). We used ordinal logistic regression models adjusted for demographic and cardiovascular factors in cross-sectional and longitudinal WMH analyses, and adjusted linear regression and linear mixed models in the analyses of cognitive function.</p><p><b>RESULTS: </b>After adjustment for confounding, higher levels of FVIII:C were not strongly associated with the burden of WMH on the initial MRI scan (OR>p75 = 1.20, 95% CI 0.99-1.45; N = 2,735) nor with WMH burden worsening over time (OR>p75 = 1.18, 95% CI 0.87-1.59; N = 1,527). High FVIII:C showed no strong association with cognitive scores cross-sectionally (3MSE>p75 β = -0.06, 95%CI -0.45 to 0.32, N = 4,005; DSST>p75 β = -0.69, 95%CI -1.52 to 0.13, N = 3,954) or over time (3MSE>p75 β = -0.07,95% CI -0.58 to 0.44, N = 2,764; DSST>p75 β = -0.22, 95% CI -0.97 to 0.53, N = 2,306) after confounding adjustment.</p><p><b>INTERPRETATION: </b>The results from this cohort study of older adult participants indicate no strong relationships between higher FVIII:C levels and WMH burden or cognitive function in cross-sectional and longitudinal analyses.</p> |
| DOI | 10.1371/journal.pone.0242062 |
| Alternate Journal | PLoS One |
| PubMed ID | 33196677 |
| PubMed Central ID | PMC7668572 |
| Grant List | HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
20/11