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Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.
Thursday,2020-11-19 11:53 America/Los_Angeles — ecterry
| Title | Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Smit, RAj, Postmus, I, Trompet, S, Barnes, MR, Warren, H, Arsenault, BJ, Chasman, DI, Cupples, AL, Hitman, GA, Krauss, RM, Li, X, Psaty, BM, Stein, CM, Rotter, JI, J Jukema, W |
| Journal | Pharmacogenomics |
| Volume | 17 |
| Issue | 15 |
| Pagination | 1621-1628 |
| Date Published | 2016 10 |
| ISSN | 1744-8042 |
| Keywords | Cholesterol, LDL, Genetic Predisposition to Disease, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pharmacogenetics, Polymorphism, Single Nucleotide, Triglycerides |
| Abstract | <p><b>AIMS: </b>To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response.</p><p><b>METHODS: </b>We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia.</p><p><b>RESULTS: </b>Lead SNPs for APOE, SORT1 and NPC1L1 were associated with a decreased LDL-c response to statin treatment, as was overall genetic predisposition for increased LDL-c levels as quantified with 59 SNPs, with a 5.4% smaller statin response per standard deviation increase in genetically raised LDL-c levels.</p><p><b>CONCLUSION: </b>Genetic predisposition for increased LDL-c level may decrease efficacy of statin therapy.</p> |
| DOI | 10.2217/pgs-2016-0091 |
| Alternate Journal | Pharmacogenomics |
| PubMed ID | 27648687 |
| PubMed Central ID | PMC5558541 |
| Grant List | DP1 OD000329 / OD / NIH HHS / United States MR/K006584/1 / / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States |
ePub date:
16/10