You are here
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
Tuesday,2020-08-04 18:10 America/Los_Angeles — ecterry
| Title | Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Cawthon, PM, Manini, T, Patel, SM, Newman, A, Travison, T, Kiel, DP, Santanasto, AJ, Ensrud, KE, Xue, Q-L, Shardell, M, Duchowny, K, Erlandson, KM, Pencina, KM, Fielding, RA, Magaziner, J, Kwok, T, Karlsson, M, Ohlsson, C, Mellström, D, Hirani, V, Ribom, E, Correa-de-Araujo, R, Bhasin, S |
| Journal | J Am Geriatr Soc |
| Volume | 68 |
| Issue | 7 |
| Pagination | 1429-1437 |
| Date Published | 2020 Jul |
| ISSN | 1532-5415 |
| Abstract | <p><b>OBJECTIVES: </b>Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).</p><p><b>DESIGN: </b>Individual-level, sex-stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow-up time ranged from 1 year for falls to 8.8 ± 2.3 years for mortality.</p><p><b>SETTING: </b>Eight prospective observational cohort studies.</p><p><b>PARTICIPANTS: </b>A total of 13,421 community-dwelling men and 4,828 community-dwelling women. MEASUREMENTS Grip strength by hand dynamometry, gait speed, and lean mass by DXA.</p><p><b>RESULTS: </b>Low grip strength (absolute or standardized to body size/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut-point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (<35.5 kg in men and <20 kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness.</p><p><b>CONCLUSION: </b>Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia. J Am Geriatr Soc 68:1429-1437, 2020.</p> |
| DOI | 10.1111/jgs.16517 |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 32633824 |
| Grant List | / / California Pacific Medical Center Foundation / BHAS16SARC2 / / Foundation for the National Institutes of Health / CAWT16SARC2 / / Foundation for the National Institutes of Health / R01 AR049439-01A1 / / Foundation for the National Institutes of Health / AG51421 / AG / NIA NIH HHS / United States R01AR057118 / AG / NIA NIH HHS / United States U24AG051129 / AG / NIA NIH HHS / United States R01 AR 41398 / AG / NIA NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States N01AG62106 / AG / NIA NIH HHS / United States N01AG62103 / AG / NIA NIH HHS / United States N01AG62101 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States R01AR35584 / AG / NIA NIH HHS / United States R01 AR35583 / AG / NIA NIH HHS / United States R01 AR35582 / AG / NIA NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States K01 AG057726 / AG / NIA NIH HHS / United States R01 AG054366 / AG / NIA NIH HHS / United States K23 AG050260 / AG / NIA NIH HHS / United States 480-10-014 / / Netherlands Organization for Scientific Research (NWO) / 301916 / / National Health and Medical Research Council / 5 P60 AR49465-03 / / NIAMS Multidisciplinary Clinical Research Center / 5-P60-AR30701 / / NIAMS Multipurpose Arthritis and Musculoskeletal Disease Center / S3486 / / Centers for Disease Control and Prevention/Association of Schools of Public Health / S043, S1734 / / Centers for Disease Control and Prevention/Association of Schools of Public Health / N01-HC-25195 / / National Heart, Lung, and Blood Institute (NHLBI) / U01HL130114 / / National Heart, Lung, and Blood Institute (NHLBI) / U01HL080295 / / National Heart, Lung, and Blood Institute (NHLBI) / N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States 2006-3832 / / Swedish Research Council / 2041657 / / Chinese University of Hong Kong / CUHK 4101/02M / / Research Grants Council Earmarked / UL1 TR000128 / TR / NCATS NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States AG51421 / AG / NIA NIH HHS / United States R01AR057118 / AG / NIA NIH HHS / United States U24AG051129 / AG / NIA NIH HHS / United States R01 AR 41398 / AG / NIA NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States N01AG62106 / AG / NIA NIH HHS / United States N01AG62103 / AG / NIA NIH HHS / United States N01AG62101 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States R01AR35584 / AG / NIA NIH HHS / United States R01 AR35583 / AG / NIA NIH HHS / United States R01 AR35582 / AG / NIA NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States K01 AG057726 / AG / NIA NIH HHS / United States R01 AG054366 / AG / NIA NIH HHS / United States K23 AG050260 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States UL1 TR000128 / TR / NCATS NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States |
ePub date:
20/07