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FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.
Monday,2020-03-23 16:18 America/Los_Angeles — ecterry
| Title | FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Fragoso, CAVaz, Van Ness, PH, McAvay, GJ |
| Journal | Respir Care |
| Volume | 65 |
| Issue | 2 |
| Pagination | 217-226 |
| Date Published | 2020 Feb |
| ISSN | 1943-3654 |
| Abstract | <p><b>BACKGROUND: </b>Commonly used thresholds for staging FEV have not been evaluated as standalone spirometric predictors of death in older persons. Specifically, the proportion of deaths attributed to a reduced FEV, when staged by commonly used thresholds in L, percent of predicted (% pred), and Z scores, has not been previously reported.</p><p><b>METHODS: </b>In 4,232 white persons ≥ 65 y old, sampled from the Cardiovascular Health Study, FEV was stratified as stage 1 (FEV ≥ 2.00 L, ≥80% pred, and Z score ≥-1.64), stage 2 (FEV 1.50-1.99 L, 50-79%pred, and Z score -2.55 to -1.63), and stage 3 (FEV < 1.50 L, < 50% pred, and Z score < -2.55). Notably, a Z score threshold of -1.64 defines normal-for-age lung function as the lower limit of normal (ie, 5th percentile of distribution), and accounts for differences in age, sex, height, and ethnicity. Next, adjusted odds ratios and average attributable fractions for 10-y all-cause mortality were calculated, comparing FEV stages 2 and 3 against stage 1, expressed in L, % pred, and Z scores. The average attributable fraction estimates the proportion of deaths attributed to a predictor by combining the prevalence of the predictor with the relative risk of death conferred by that predictor.</p><p><b>RESULTS: </b>FEV stage 2 and 3 in L, % pred, and Z scores yielded similar adjusted odds ratios of death: 1.40-1.51 for stage 2 and 2.35-2.66 for stage 3. Conversely, FEV stages 2 and 3 in L, % pred, and Z scores differed in prevalence: 12.8-28.6% for stage 2 and 6.4-17.5% for stage 3, and also differed in the adjusted average attributable fraction for death: 3.2-6.4% for stage 2 and 4.5-9.1% for stage 3.</p><p><b>CONCLUSIONS: </b>In older persons, the proportion of deaths attributed to a reduced FEV is best stratified by Z score staging thresholds because these yield a similar relative risk of death but a more age- and sex-appropriate prevalence of FEV stage.</p> |
| DOI | 10.4187/respcare.07012 |
| Alternate Journal | Respir Care |
| PubMed ID | 31662447 |
| Grant List | P30 AG021342 / AG / NIA NIH HHS / United States |
ePub date:
20/02