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Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease.
Wednesday,2019-12-04 15:59 America/Los_Angeles — ecterry
| Title | Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Sáez, ME, González-Pérez, A, Hernández-Olasagarre, B, Beà, A, Moreno-Grau, S, de Rojas, I, Monté-Rubio, G, Orellana, A, Valero, S, Comella, JX, Sanchís, D, Ruiz, A |
| Journal | Sci Rep |
| Volume | 9 |
| Issue | 1 |
| Pagination | 16665 |
| Date Published | 2019 Nov 13 |
| ISSN | 2045-2322 |
| Abstract | <p>Echocardiography has become an indispensable tool for the study of heart performance, improving the monitoring of individuals with cardiac diseases. Diverse genetic factors associated with echocardiographic measures have been previously reported. The impact of several apoptotic genes in heart development identified in experimental models prompted us to assess their potential association with human cardiac function. This study aimed at investigating the possible association of variants of apoptotic genes with echocardiographic traits and to identify new genetic markers associated with cardiac function. Genome wide data from different studies were obtained from public repositories. After quality control and imputation, a meta-analysis of individual association study results was performed. Our results confirmed the role of caspases and other apoptosis related genes with cardiac phenotypes. Moreover, enrichment analysis showed an over-representation of genes, including some apoptotic regulators, associated with Alzheimer's disease. We further explored this unexpected observation which was confirmed by genetic correlation analyses. Our findings show the association of apoptotic gene variants with echocardiographic indicators of heart function and reveal a novel potential genetic link between echocardiographic measures in healthy populations and cognitive decline later on in life. These findings may have important implications for preventative strategies combating Alzheimer's disease.</p> |
| DOI | 10.1038/s41598-019-52724-2 |
| Alternate Journal | Sci Rep |
| PubMed ID | 31723151 |
| PubMed Central ID | PMC6853976 |
| Grant List | HHSN268201500003C / HL / NHLBI NIH HHS / United States U01 AG046152 / AG / NIA NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States N01HC48049 / HL / NHLBI NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States R01 AG030146 / AG / NIA NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States N01 HC085085 / HC / NHLBI NIH HHS / United States R01 AG017917 / AG / NIA NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N02HL64278 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States U01 HG004729 / HG / NHGRI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States N01HC95095 / HL / NHLBI NIH HHS / United States R01 AG032990 / AG / NIA NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States R01 NS080820 / NS / NINDS NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States N01HC65226 / HL / NHLBI NIH HHS / United States U01 AG046139 / AG / NIA NIH HHS / United States N01 HC085084 / HC / NHLBI NIH HHS / United States N01HC48050 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC48047 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States P01 AG003949 / AG / NIA NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States P50 AG025711 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States P01 AG017216 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R01 AG023193 / AG / NIA NIH HHS / United States R01 AG018023 / AG / NIA NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States R01 AG036836 / AG / NIA NIH HHS / United States R01 AG015819 / AG / NIA NIH HHS / United States N01HC48048 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
19/11