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Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.
Monday,2019-03-18 15:52 America/Los_Angeles — ecterry
| Title | Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Peloso, GM, van der Lee, SJ, DeStefano, AL, Seshardi, S |
| Corporate/Institutional Authors | International Genomics of Alzheimer's Project (IGAP) |
| Journal | Alzheimers Dement (Amst) |
| Volume | 10 |
| Pagination | 595-598 |
| Date Published | 2018 |
| ISSN | 2352-8729 |
| Abstract | <p><b>Introduction: </b>There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein () locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.</p><p><b>Methods: </b>Ten single nucleotide polymorphisms within the locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.</p><p><b>Results: </b>Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the locus, we found that HDL-C was not associated with risk of AD ( > .7).</p><p><b>Discussion: </b>Our study does not support the role of HDL-C on risk of AD through HDL-C altered by . This study does not rule out other mechanisms by which HDL-C affects risk of AD.</p> |
| DOI | 10.1016/j.dadm.2018.08.008 |
| Alternate Journal | Alzheimers Dement (Amst) |
| PubMed ID | 30422133 |
| PubMed Central ID | PMC6215982 |
| Grant List | P30 AG053760 / AG / NIA NIH HHS / United States R01 AG058501 / AG / NIA NIH HHS / United States P01 AG003991 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States |
ePub date:
18/09