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Validation of the REGARDS Severe Sepsis Risk Score.
Wednesday,2019-01-09 13:17 America/Los_Angeles — ecterry
| Title | Validation of the REGARDS Severe Sepsis Risk Score. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Wang, HE, Donnelly, JP, Yende, S, Levitan, EB, Shapiro, NI, Dai, Y, Zhao, H, Heiss, G, Odden, M, Newman, A, Safford, M |
| Journal | J Clin Med |
| Volume | 7 |
| Issue | 12 |
| Date Published | 2018 Dec 11 |
| ISSN | 2077-0383 |
| Abstract | <p>There are no validated systems for characterizing long-term risk of severe sepsis in community-dwelling adults. We tested the ability of the REasons for Geographic and Racial Differences in Stroke-Severe Sepsis Risk Score (REGARDS-SSRS) to predict 10-year severe sepsis risk in separate cohorts of community-dwelling adults. We internally tested the REGARDS-SSRS on the REGARDS-Medicare subcohort. We then externally validated the REGARDS-SSRS using (1) the Cardiovascular Health Study (CHS) and (2) the Atherosclerosis Risk in Communities (ARIC) cohorts. Participants included community-dwelling adults: REGARDS-Medicare, age ≥65 years, = 9522; CHS, age ≥65 years, = 5888; ARIC, age 45⁻64 years, = 11,584. The primary exposure was 10-year severe sepsis risk, predicted by the REGARDS-SSRS from participant sociodemographics, health behaviors, chronic medical conditions and select biomarkers. The primary outcome was first severe sepsis hospitalizations, defined as the concurrent presence of ICD-9 discharge diagnoses for a serious infection and organ dysfunction. Median SSRS in the cohorts were: REGARDS-Medicare 11 points (IQR 7⁻16), CHS 10 (IQR 6⁻15), ARIC 7 (IQR 5⁻10). Severe sepsis incidence rates were: REGARDS-Medicare 30.7 per 1000 person-years (95% CI: 29.2⁻32.2); CHS 11.9 (10.9⁻12.9); ARIC 6.8 (6.3⁻7.3). SSRS discrimination for first severe sepsis events were: REGARDS-Medicare C-statistic 0.704 (95% CI: 0.691⁻0.718), CHS 0.696 (0.675⁻0.716), ARIC 0.697 (0.677⁻0.716). The REGARDS-SRSS may potentially play a role in identifying community-dwelling adults at high severe sepsis risk.</p> |
| DOI | 10.3390/jcm7120536 |
| Alternate Journal | J Clin Med |
| PubMed ID | 30544923 |
| PubMed Central ID | PMC6306847 |
| Grant List | R01-NR012726 / / National Institutes of Health / |
ePub date:
18/12