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Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.
Tuesday,2018-05-01 17:38 America/Los_Angeles — ecterry
| Title | Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Gong, J, Nishimura, KK, Fernandez-Rhodes, L, Haessler, J, Bien, S, Graff, M, Lim, U, Lu, Y, Gross, M, Fornage, M, Yoneyama, S, Isasi, CR, Bůžková, P, Daviglus, M, Lin, D-Y, Tao, R, Goodloe, R, Bush, WS, Farber-Eger, E, Boston, J, Dilks, HH, Ehret, G, Gu, CC, Lewis, CE, Nguyen, K-DH, Cooper, R, Leppert, M, Irvin, MR, Bottinger, EP, Wilkens, LR, Haiman, CA, Park, L, Monroe, KR, Cheng, I, Stram, DO, Carlson, CS, Jackson, R, Kuller, L, Houston, D, Kooperberg, C, Buyske, S, Hindorff, LA, Crawford, DC, Loos, RJF, Le Marchand, L, Matise, TC, North, KE, Peters, U |
| Journal | Int J Obes (Lond) |
| Volume | 42 |
| Issue | 3 |
| Pagination | 384-390 |
| Date Published | 2018 Mar |
| ISSN | 1476-5497 |
| Abstract | <p><b>OBJECTIVE: </b>Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been shown to be a heritable, polygenic trait, with close to 100 loci previously identified and replicated in multiple populations. We aim to replicate known BMI loci and identify novel associations in a trans-ethnic study population.</p><p><b>SUBJECTS: </b>Using eligible participants from the Population Architecture using Genomics and Epidemiology consortium, we conducted a trans-ethnic meta-analysis of 102 514 African Americans, Hispanics, Asian/Native Hawaiian, Native Americans and European Americans. Participants were genotyped on over 200 000 SNPs on the Illumina Metabochip custom array, or imputed into the 1000 Genomes Project (Phase I). Linear regression of the natural log of BMI, adjusting for age, sex, study site (if applicable), and ancestry principal components, was conducted for each race/ethnicity within each study cohort. Race/ethnicity-specific, and combined meta-analyses used fixed-effects models.</p><p><b>RESULTS: </b>We replicated 15 of 21 BMI loci included on the Metabochip, and identified two novel BMI loci at 1q41 (rs2820436) and 2q31.1 (rs10930502) at the Metabochip-wide significance threshold (P<2.5 × 10). Bioinformatic functional investigation of SNPs at these loci suggests a possible impact on pathways that regulate metabolism and adipose tissue.</p><p><b>CONCLUSION: </b>Conducting studies in genetically diverse populations continues to be a valuable strategy for replicating known loci and uncovering novel BMI associations.</p> |
| DOI | 10.1038/ijo.2017.304 |
| Alternate Journal | Int J Obes (Lond) |
| PubMed ID | 29381148 |
| PubMed Central ID | PMC5876082 |
| Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States U01 HG007417 / HG / NHGRI NIH HHS / United States N01WH42129 / WH / WHI NIH HHS / United States UL1 RR033176 / RR / NCRR NIH HHS / United States N01WH32111 / WH / WHI NIH HHS / United States N01WH32100 / WH / WHI NIH HHS / United States N01WH42125 / WH / WHI NIH HHS / United States HHSN268201100001I / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States N01WH42124 / WH / WHI NIH HHS / United States UL1 TR000445 / TR / NCATS NIH HHS / United States HHSN268201300026C / HL / NHLBI NIH HHS / United States N01WH32109 / WH / WHI NIH HHS / United States U01 HG007419 / HG / NHGRI NIH HHS / United States N01WH32122 / WH / WHI NIH HHS / United States U01 HL041642 / HL / NHLBI NIH HHS / United States UM1 CA164973 / CA / NCI NIH HHS / United States N01WH42120 / WH / WHI NIH HHS / United States N01WH44221 / WH / WHI NIH HHS / United States U01 HL041654 / HL / NHLBI NIH HHS / United States N01WH42132 / WH / WHI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States N01WH24152 / WH / WHI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States N01WH42111 / WH / WHI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HG004790 / HG / NHGRI NIH HHS / United States N01WH32102 / WH / WHI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States N01HC48049 / HL / NHLBI NIH HHS / United States HHSN268201100004I / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States U01 HG004802 / HG / NHGRI NIH HHS / United States U01 HG007416 / HG / NHGRI NIH HHS / United States N01HC45205 / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States N01WH42123 / WH / WHI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01WH42109 / WH / WHI NIH HHS / United States HHSN268201100046C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States N01WH32118 / WH / WHI NIH HHS / United States R25 CA094880 / CA / NCI NIH HHS / United States N01HC65236 / HL / NHLBI NIH HHS / United States HHSN268201100003C / WH / WHI NIH HHS / United States U01 HG007376 / HG / NHGRI NIH HHS / United States N01HC65235 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States N01WH42115 / WH / WHI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States HHSN268201300025C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 HL041652 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC65234 / HL / NHLBI NIH HHS / United States N01WH32115 / WH / WHI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States N01WH32106 / WH / WHI NIH HHS / United States HHSN268201300027C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States N01HC65233 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 DK101855 / DK / NIDDK NIH HHS / United States N01HC95095 / HL / NHLBI NIH HHS / United States N1WH42116A / WH / WHI NIH HHS / United States N01WH42119 / WH / WHI NIH HHS / United States HHSN268200900041C / HL / NHLBI NIH HHS / United States HHSN268201300028C / HL / NHLBI NIH HHS / United States N01HC65237 / HL / NHLBI NIH HHS / United States U01 HG004803 / HG / NHGRI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN271201100004C / AG / NIA NIH HHS / United States N01WH42131 / WH / WHI NIH HHS / United States R01 CA063464 / CA / NCI NIH HHS / United States P01 CA033619 / CA / NCI NIH HHS / United States N01 HC045134 / HC / NHLBI NIH HHS / United States HHSN268201100002C / WH / WHI NIH HHS / United States UL1 TR001073 / TR / NCATS NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N1WH42112A / HL / NHLBI NIH HHS / United States N01WH42130 / WH / WHI NIH HHS / United States N01 HC085081 / HC / WHI NIH HHS / United States N01WH42107 / WH / WHI NIH HHS / United States N01WH32105 / WH / WHI NIH HHS / United States N01HC48050 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC05187 / HL / NHLBI NIH HHS / United States N01WH42121 / WH / WHI NIH HHS / United States N01WH32113 / WH / WHI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States N01HC48047 / HL / NHLBI NIH HHS / United States T32 HD007168 / HD / NICHD NIH HHS / United States U01 CA098758 / CA / NCI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01WH42118 / WH / WHI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States N01WH32101 / WH / WHI NIH HHS / United States U01 HL065521 / HL / NHLBI NIH HHS / United States N1WH42114A / HL / NHLBI NIH HHS / United States N01WH42126 / WH / WHI NIH HHS / United States S10 OD020069 / OD / NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States U01 HG004798 / HG / NHGRI NIH HHS / United States HHSN268201100002I / HL / NHLBI NIH HHS / United States N01WH42113 / WH / WHI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States HHSN268201300029C / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States T32 HL007055 / HL / NHLBI NIH HHS / United States N01WH32119 / WH / WHI NIH HHS / United States U01 CA136792 / CA / NCI NIH HHS / United States R01 HL109301 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01WH42117 / WH / WHI NIH HHS / United States U01 HG007397 / HG / NHGRI NIH HHS / United States U01 CA164973 / CA / NCI NIH HHS / United States N01WH32108 / WH / WHI NIH HHS / United States R37 CA054281 / CA / NCI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States HHSN268201100001C / WH / WHI NIH HHS / United States N01WH22110 / WH / WHI NIH HHS / United States R01 HL055673 / HL / NHLBI NIH HHS / United States U01 HL065520 / HL / NHLBI NIH HHS / United States N01WH42108 / WH / WHI NIH HHS / United States HHSN268201100004C / WH / WHI NIH HHS / United States N01 HC065235 / HC / WHI NIH HHS / United States N01HC48048 / HL / NHLBI NIH HHS / United States N01WH42122 / WH / WHI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01WH42110 / WH / WHI NIH HHS / United States U01 HG004801 / HG / NHGRI NIH HHS / United States N01WH32112 / WH / WHI NIH HHS / United States |
ePub date:
18/03