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Association of lipoprotein-associated phospholipase A and risk of incident atrial fibrillation: Findings from 3 cohorts.
Tuesday,2018-05-01 17:38 America/Los_Angeles — ecterry
| Title | Association of lipoprotein-associated phospholipase A and risk of incident atrial fibrillation: Findings from 3 cohorts. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Garg, PK, Bartz, TM, Norby, FL, Jorgensen, NW, McClelland, RL, Ballantyne, CM, Chen, LY, Gottdiener, JS, Greenland, P, Hoogeveen, R, Jenny, NS, Kizer, JR, Rosenson, RS, Soliman, EZ, Cushman, M, Alonso, A, Heckbert, SR |
| Journal | Am Heart J |
| Volume | 197 |
| Pagination | 62-69 |
| Date Published | 2018 Mar |
| ISSN | 1097-6744 |
| Abstract | <p><b>BACKGROUND: </b>Multiple prospective studies have established an association between inflammation and higher risk of atrial fibrillation (AF), but the association between lipoprotein-associated phospholipase A (Lp-PLA) mass and activity and incident AF has not been extensively evaluated.</p><p><b>METHODS: </b>Using data from 10,794 Atherosclerosis Risk In Communities (ARIC) study participants aged 53-75 years, 5,181 Cardiovascular Health Study (CHS) participants aged 65 to 100 years, and 5,425 Multi-Ethnic Study of Atherosclerosis (MESA) participants aged 45-84 years, we investigated the association between baseline Lp-PLA levels and the risk of developing AF. Incident AF was identified in each cohort by follow-up visit electrocardiograms, hospital discharge coding of AF, or Medicare claims data.</p><p><b>RESULTS: </b>Over a mean of 13.1, 11.5, and 10.0 years of follow-up, 1,439 (13%), 2,084 (40%), and 615 (11%) incident AF events occurred in ARIC, CHS, and MESA, respectively. In adjusted analyses, each SD increment in Lp-PLA activity was associated with incident AF in both ARIC (hazard ratio [HR] 1.13, 95% CI 1.06-1.20) and MESA (HR 1.24, 95% CI 1.05-1.46). Each SD increment in Lp-PLA mass was also associated with incident AF in MESA (HR 1.25, 95% CI 1.11-1.41). No significant associations were observed among CHS participants.</p><p><b>CONCLUSIONS: </b>Although higher Lp-PLA mass and activity were associated with development of AF in ARIC and MESA, this relationship was not observed in CHS, a cohort of older individuals.</p> |
| DOI | 10.1016/j.ahj.2017.11.010 |
| Alternate Journal | Am. Heart J. |
| PubMed ID | 29447785 |
| PubMed Central ID | PMC5860682 |
| Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States R01 HL126637 / HL / NHLBI NIH HHS / United States |
ePub date:
18/03