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Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131).
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Prevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131). |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Scuteri, A, Manolio, TA, Marino, EK, Arnold, AM, Lakatta, EG |
| Journal | J Am Coll Cardiol |
| Volume | 43 |
| Issue | 2 |
| Pagination | 187-93 |
| Date Published | 2004 Jan 21 |
| ISSN | 0735-1097 |
| Keywords | Aged, Cardiovascular Diseases, Carotid Arteries, Female, Humans, Hypertrophy, Incidence, Male, Predictive Value of Tests, Prevalence, Prospective Studies, Ultrasonography |
| Abstract | <p><b>OBJECTIVES: </b>We hypothesized that variant geometric patterns of the common carotid artery (CCA) predict the incidence of cardiovascular disease (CVD), after accounting for CCA intima-medial thickness (IMT).</p><p><b>BACKGROUND: </b>Common carotid artery intima-media thickness has been associated with the incidence of cardiovascular disease.</p><p><b>METHOD: </b>Noninvasive measurements of IMT were made with high-resolution ultrasonography in 5,640 subjects 65 years of age or older participating in the Cardiovascular Health Study. New coronary and/or cerebrovascular events served as outcome variables over a median 10.2-year follow-up. To characterize different carotid structural geometric patterns (CGP), vascular mass (VM) was combined with the wall-to-lumen ratio (W/L). Normal values for W/L and VM were defined as age-adjusted, gender-specific 75th percentiles of the 1,899 normotensive subjects free of CVD at baseline. Four CGPs were defined: CGP1 = normal W/L ratio and VM; CGP2 = arterial remodeling (i.e., increased W/L ratio with normal VM); CGP3 = arterial hypertrophy (i.e., increased W/L ratio with increased VM); and CGP4 = arterial hypertrophy with dilation (i.e., normal W/L ratio and increased VM).</p><p><b>RESULTS: </b>Coronary or cerebrovascular events (adjusted for age, gender, traditional risk factors, and IMT) were associated with CGP in subjects free of CVD at baseline. Specifically, the hazard ratio (Cox proportional-hazards analyses) for CGP3 (arterial hypertrophy) was 1.25 (95% confidence interval [CI] 1.03 to 1.53), and for CGP4 (arterial hypertrophy with dilation) was 1.43 (95% CI 1.16 to 1.75) compared with CGP1 (normal).</p><p><b>CONCLUSIONS: </b>Arterial hypertrophy defined by variant CGP patterns is associated with the development of new CVD, independent of age, traditional risk factors, and CCA IMT.</p> |
| DOI | 10.1016/j.jacc.2003.08.035 |
| Alternate Journal | J Am Coll Cardiol |
| PubMed ID | 14736436 |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |