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Telomeres and the natural lifespan limit in humans.
Tuesday,2018-01-16 18:34 America/Los_Angeles — ecterry
| Title | Telomeres and the natural lifespan limit in humans. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Steenstrup, T, Kark, JD, Verhulst, S, Thinggaard, M, Hjelmborg, JVB, Dalgård, C, Kyvik, KO, Christiansen, L, Mangino, M, Spector, TD, Petersen, I, Kimura, M, Benetos, A, Labat, C, Sinnreich, R, Hwang, S-J, Levy, D, Hunt, SC, Fitzpatrick, AL, Chen, W, Berenson, GS, Barbieri, M, Paolisso, G, Gadalla, SM, Savage, SA, Christensen, K, Yashin, AI, Arbeev, KG, Aviv, A |
| Journal | Aging (Albany NY) |
| Volume | 9 |
| Issue | 4 |
| Pagination | 1130-1142 |
| Date Published | 2017 Apr |
| ISSN | 1945-4589 |
| Abstract | <p>An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.</p> |
| DOI | 10.18632/aging.101216 |
| Alternate Journal | Aging (Albany NY) |
| PubMed ID | 28394764 |
| PubMed Central ID | PMC5425118 |
| Grant List | U10 HL054472 / HL / NHLBI NIH HHS / United States U01 HL054472 / HL / NHLBI NIH HHS / United States U01 HL054471 / HL / NHLBI NIH HHS / United States U01 HL054496 / HL / NHLBI NIH HHS / United States U10 HL054509 / HL / NHLBI NIH HHS / United States R01 HL116446 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States U01 HL054509 / HL / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States R01 AG016592 / AG / NIA NIH HHS / United States R01 ES021724 / ES / NIEHS NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States R01 HL080698 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States P30 AG034424 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States R01 HD071180 / HD / NICHD NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States / / Wellcome Trust / United Kingdom U10 HL054473 / HL / NHLBI NIH HHS / United States U10 HL054495 / HL / NHLBI NIH HHS / United States U10 HL054496 / HL / NHLBI NIH HHS / United States U10 HL054471 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG027058 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States U01 HL054495 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States R01 HL055673 / HL / NHLBI NIH HHS / United States U01 HL054473 / HL / NHLBI NIH HHS / United States |
ePub date:
17/04