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Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
Tuesday,2018-01-16 18:26 America/Los_Angeles — ecterry
| Title | Genetic loci associated with heart rate variability and their effects on cardiac disease risk. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Nolte, IM, M Munoz, L, Tragante, V, Amare, AT, Jansen, R, Vaez, A, von der Heyde, B, Avery, CL, Bis, JC, Dierckx, B, van Dongen, J, Gogarten, SM, Goyette, P, Hernesniemi, J, Huikari, V, Hwang, S-J, Jaju, D, Kerr, KF, Kluttig, A, Krijthe, BP, Kumar, J, van der Laan, SW, Lyytikäinen, L-P, Maihofer, AX, Minassian, A, van der Most, PJ, Müller-Nurasyid, M, Nivard, M, Salvi, E, Stewart, JD, Thayer, JF, Verweij, N, Wong, A, Zabaneh, D, Zafarmand, MH, Abdellaoui, A, Albarwani, S, Albert, C, Alonso, A, Ashar, F, Auvinen, J, Axelsson, T, Baker, DG, de Bakker, PIW, Barcella, M, Bayoumi, R, Bieringa, RJ, Boomsma, D, Boucher, G, Britton, AR, Christophersen, I, Dietrich, A, Ehret, GB, Ellinor, PT, Eskola, M, Felix, JF, Floras, JS, Franco, OH, Friberg, P, Gademan, MGJ, Geyer, MA, Giedraitis, V, Hartman, CA, Hemerich, D, Hofman, A, Hottenga, J-J, Huikuri, H, Hutri-Kähönen, N, Jouven, X, Junttila, J, Juonala, M, Kiviniemi, AM, Kors, JA, Kumari, M, Kuznetsova, T, Laurie, CC, Lefrandt, JD, Li, Y, Li, Y, Liao, D, Limacher, MC, Lin, HJ, Lindgren, CM, Lubitz, SA, Mahajan, A, McKnight, B, Schwabedissen, HMeyer Zu, Milaneschi, Y, Mononen, N, Morris, AP, Nalls, MA, Navis, G, Neijts, M, Nikus, K, North, KE, O'Connor, DT, Ormel, J, Perz, S, Peters, A, Psaty, BM, Raitakari, OT, Risbrough, VB, Sinner, MF, Siscovick, D, Smit, JH, Smith, NL, Soliman, EZ, Sotoodehnia, N, Staessen, JA, Stein, PK, Stilp, AM, Stolarz-Skrzypek, K, Strauch, K, Sundström, J, Swenne, CA, Syvänen, A-C, Tardif, J-C, Taylor, KD, Teumer, A, Thornton, TA, Tinker, LE, Uitterlinden, AG, van Setten, J, Voss, A, Waldenberger, M, Wilhelmsen, KC, Willemsen, G, Wong, Q, Zhang, Z-M, Zonderman, AB, Cusi, D, Evans, MK, Greiser, HK, van der Harst, P, Hassan, M, Ingelsson, E, Jarvelin, M-R, Kääb, S, Kähönen, M, Kivimaki, M, Kooperberg, C, Kuh, D, Lehtimäki, T, Lind, L, Nievergelt, CM, O'Donnell, CJ, Oldehinkel, AJ, Penninx, B, Reiner, AP, Riese, H, van Roon, AM, Rioux, JD, Rotter, JI, Sofer, T, Stricker, BH, Tiemeier, H, Vrijkotte, TGM, Asselbergs, FW, Brundel, BJJM, Heckbert, SR, Whitsel, EA, Hoed, Mden, Snieder, H, de Geus, EJC |
| Journal | Nat Commun |
| Volume | 8 |
| Pagination | 15805 |
| Date Published | 2017 Jun 14 |
| ISSN | 2041-1723 |
| Abstract | <p>Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74<rg<-0.55) and blood pressure (-0.35<rg<-0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.</p> |
| DOI | 10.1038/ncomms15805 |
| Alternate Journal | Nat Commun |
| PubMed ID | 28613276 |
| PubMed Central ID | PMC5474732 |
| Grant List | I01 BX002558 / BX / BLRD VA / United States P01 GM099568 / GM / NIGMS NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States |
ePub date:
17/06