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Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.
Tuesday,2018-01-16 17:00 America/Los_Angeles — ecterry
| Title | Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Chibnik, LB, Wolters, FJ, Bäckman, K, Beiser, A, Berr, C, Bis, JC, Boerwinkle, E, Bos, D, Brayne, C, Dartigues, J-F, Darweesh, SKL, Debette, S, Davis-Plourde, KL, Dufouil, C, Fornage, M, Grasset, L, Gudnason, V, Hadjichrysanthou, C, Helmer, C, Ikram, AM, M Ikram, K, Kern, S, Kuller, LH, Launer, L, Lopez, OL, Matthews, F, Meirelles, O, Mosley, T, Ower, A, Psaty, BM, Satizabal, CL, Seshadri, S, Skoog, I, Stephan, BCM, Tzourio, C, Waziry, R, Wong, MMei, Zettergren, A, Hofman, A |
| Journal | Eur J Epidemiol |
| Volume | 32 |
| Issue | 10 |
| Pagination | 931-938 |
| Date Published | 2017 Oct |
| ISSN | 1573-7284 |
| Abstract | <p>Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.</p> |
| DOI | 10.1007/s10654-017-0320-5 |
| Alternate Journal | Eur. J. Epidemiol. |
| PubMed ID | 29063414 |
| PubMed Central ID | PMC5680377 |
| Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States N01AG12100 / AG / NIA NIH HHS / United States R01 AG054076 / AG / NIA NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01 AG049607 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States R01 AG008122 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States HHSN271201200022C / AG / NIA NIH HHS / United States R01 AG033040 / AG / NIA NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States U01 AG049505 / AG / NIA NIH HHS / United States |
ePub date:
17/10