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The Association Between IGF-I and IGFBP-3 and Incident Diabetes in an Older Population of Men and Women in the Cardiovascular Health Study.
Tuesday,2018-01-16 16:53 America/Los_Angeles — ecterry
| Title | The Association Between IGF-I and IGFBP-3 and Incident Diabetes in an Older Population of Men and Women in the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Aneke-Nash, CS, Xue, XN, Qi, Q, Biggs, ML, Cappola, A, Kuller, L, Pollak, M, Psaty, BM, Siscovick, D, Mukamal, K, Strickler, HD, Kaplan, RC |
| Journal | J Clin Endocrinol Metab |
| Volume | 102 |
| Issue | 12 |
| Pagination | 4541-4547 |
| Date Published | 2017 Dec 01 |
| ISSN | 1945-7197 |
| Keywords | Aged, Aged, 80 and over, Biomarkers, Blood Glucose, Cardiovascular Diseases, Cohort Studies, Diabetes Mellitus, Female, Humans, Incidence, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Longitudinal Studies, Male, New England, Prospective Studies, Risk |
| Abstract | <p><b>Context: </b>Insulin-like growth factor-I (IGF-I) has structural and functional similarities to insulin and may play a role in glucose homeostasis, along with insulin-like growth factor binding protein-3 (IGFBP-3), which binds the majority of circulating IGF-I.</p><p><b>Objective: </b>To assess whether IGF-I and IGFBP-3 are associated with a higher risk of incident diabetes in older adults.</p><p><b>Design: </b>Participants in the Cardiovascular Health Study (n = 3133), a cohort of adults aged ≥65 years, were observed for 16 years (n = 3133) for the development of incident diabetes. Statistical models were fit separately for men and women because of interactions with sex (P interaction: IGF-I, 0.02; IGFBP-3, 0.009) and were adjusted for relevant covariates.</p><p><b>Setting: </b>General community.</p><p><b>Participants: </b>Older adults who were nondiabetic at baseline and who did not develop diabetes within the first year of follow-up.</p><p><b>Interventions: </b>Not applicable.</p><p><b>Main Outcome Measure: </b>Incident diabetes as measured by fasting plasma glucose (FPG) ≥126 mg/dL, non-FPG ≥200 mg/dL, use of pharmacological treatment of diabetes, or existence of two or more inpatient or three or more outpatient or (at least one inpatient and at least one outpatient) Centers for Medicare & Medicaid Services claims with the diagnostic International Classification of Diseases, Ninth Revision, Clinical Modification code of 250.xx.</p><p><b>Results: </b>In women, higher IGFBP-3 (hazard ratio tertile 3 vs tertile 1 = 2.30; 95% confidence interval, 1.55 to 3.40; P trend < 0.0001) was significantly associated with incident diabetes. Total IGF-I was not significantly associated with incident diabetes. In men, neither IGF-I nor IGFBP-3 was significantly associated with incident diabetes.</p><p><b>Conclusions: </b>We confirmed a previously reported association between circulating IGFBP-3 and diabetes risk in the older adult population, establishing that this association is present among women but could not be shown to be associated in men.</p> |
| DOI | 10.1210/jc.2017-01273 |
| Alternate Journal | J. Clin. Endocrinol. Metab. |
| PubMed ID | 29040592 |
| PubMed Central ID | PMC5718696 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States T32 GM007288 / GM / NIGMS NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
12/17