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Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.
Tuesday,2018-01-16 16:52 America/Los_Angeles — ecterry
| Title | Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Armstrong, NM, Carlson, MC, Xue, Q-L, Schrack, J, Carnethon, MR, Chaves, PHM, Gross, AL |
| Journal | J Aging Health |
| Pagination | 898264317744921 |
| Date Published | 2017 Nov 01 |
| ISSN | 1552-6887 |
| Abstract | <p><b>OBJECTIVES: </b>To evaluate whether late-life depression mediates the association of subclinical cardiovascular disease (CVD) with all-cause mortality.</p><p><b>METHOD: </b>Using data from 3,473 Cardiovascular Health Study participants, the Cox proportional hazards model was used to examine the direct and indirect (via late-life depression) effects of the association between baseline subclinical CVD and all-cause mortality with weights derived from multivariable logistic regression of late-life depression on subclinical CVD.</p><p><b>RESULTS: </b>Subclinical CVD led to a higher risk of all-cause mortality (hazard ratio [HR] = 1.51, 95% confidence interval, [CI] = [1.42, 1.94]). Total effect of subclinical CVD on all-cause mortality was decomposed into direct (HR = 1.41, 95% CI = [1.37, 1.58]) and indirect (HR = 1.07, 95% CI = [1.01, 1.23]) effects; 16.3% of the total effect of subclinical CVD on all-cause mortality was mediated by late-life depression.</p><p><b>DISCUSSION: </b>Late-life depression accounts for little, if any, of the association between subclinical CVD, a risk factor of all-cause mortality, and all-cause mortality.</p> |
| DOI | 10.1177/0898264317744921 |
| Alternate Journal | J Aging Health |
| PubMed ID | 29254423 |
ePub date:
11/17