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Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study.
Tuesday,2012-11-06 12:06 America/Los_Angeles — eenright
| Title | Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Aleksic, N, Folsom, AR, Cushman, M, Heckbert, SR, Tsai, MY, Wu, KK |
| Journal | J Thromb Haemost |
| Volume | 1 |
| Issue | 1 |
| Pagination | 88-94 |
| Date Published | 2003 Jan |
| ISSN | 1538-7933 |
| Keywords | Age Factors, Aged, Amino Acid Substitution, Case-Control Studies, Female, Genotype, Humans, Incidence, Male, Polymorphism, Genetic, Prevalence, Prospective Studies, Risk Factors, Thromboembolism, Thrombomodulin, Venous Thrombosis |
| Abstract | <p>Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex. Venous thromboembolic events were identified in adults in two longitudinal cohort studies, the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study, totaling 21 690 participants. After 8 years of follow-up, sTM was measured in baseline plasma of 305 participants who developed venous thrombosis and 607 who did not. Thrombomodulin A455V genotype was determined in 302 cases and 626 controls. There was no difference in the prevalence of the three TM genotypes between cases and controls and no difference in age-adjusted mean values of sTM by genotype. There were no associations of age-adjusted sTM or TMA455V genotype with overall venous thromboembolism or with thrombosis in any subtype of venous thromboembolism.</p> |
| DOI | 10.1046/j.1538-7836.2003.00029.x |
| Alternate Journal | J Thromb Haemost |
| PubMed ID | 12871544 |
| Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 HL59367 / HL / NHLBI NIH HHS / United States |