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Vitamin D and Memory Decline: Two Population-Based Prospective Studies.
Friday,2016-04-01 10:46 America/Los_Angeles — zdrager
| Title | Vitamin D and Memory Decline: Two Population-Based Prospective Studies. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kuźma, E, Soni, M, Littlejohns, TJ, Ranson, JM, van Schoor, NM, Deeg, DJH, Comijs, H, Chaves, PHM, Kestenbaum, BR, Kuller, LH, Lopez, OL, Becker, JT, Langa, KM, Henley, WE, Lang, IA, Ukoumunne, OC, Llewellyn, DJ |
| Journal | J Alzheimers Dis |
| Volume | 50 |
| Issue | 4 |
| Pagination | 1099-108 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Abstract | <p><b>BACKGROUND: </b>Vitamin D deficiency has been linked with dementia risk, cognitive decline, and executive dysfunction. However, the association with memory remains largely unknown.</p><p><b>OBJECTIVE: </b>To investigate whether low serum 25-hydroxyvitamin D (25(OH)D) concentrations are associated with memory decline.</p><p><b>METHODS: </b>We used data on 1,291 participants from the US Cardiovascular Health Study (CHS) and 915 participants from the Dutch Longitudinal Aging Study Amsterdam (LASA) who were dementia-free at baseline, had valid vitamin D measurements, and follow-up memory assessments. The Benton Visual Retention Test (in the CHS) and Rey's Auditory Verbal Learning Test (in the LASA) were used to assess visual and verbal memory, respectively.</p><p><b>RESULTS: </b>In the CHS, those moderately and severely deficient in serum 25(OH)D changed -0.03 SD (95% CI: -0.06 to 0.01) and -0.10 SD (95% CI: -0.19 to -0.02) per year respectively in visual memory compared to those sufficient (p = 0.02). In the LASA, moderate and severe deficiency in serum 25(OH)D was associated with a mean change of 0.01 SD (95% CI: -0.01 to 0.02) and -0.01 SD (95% CI: -0.04 to 0.02) per year respectively in verbal memory compared to sufficiency (p = 0.34).</p><p><b>CONCLUSIONS: </b>Our findings suggest an association between severe vitamin D deficiency and visual memory decline but no association with verbal memory decline. They warrant further investigation in prospective studies assessing different memory subtypes.</p> |
| DOI | 10.3233/JAD-150811 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26836174 |
| Grant List | AG023629 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States AG20098 / AG / NIA NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HHSN26820800007C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States HL084443 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States |