You are here
Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis.
Monday,2015-12-14 09:52 America/Los_Angeles — zdrager
| Title | Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Bell, EJ, Folsom, AR, Lutsey, PL, Selvin, E, Zakai, NA, Cushman, M, Alonso, A |
| Journal | Diabetes Res Clin Pract |
| Volume | 111 |
| Pagination | 10-8 |
| Date Published | 2016 Jan |
| ISSN | 1872-8227 |
| Abstract | <p><b>UNLABELLED: </b>Diabetes mellitus (DM) may be a risk factor for venous thromboembolism (VTE) but results are inconsistent.</p><p><b>AIM: </b>We conducted a systematic review and meta-analysis of epidemiologic studies to quantify the association between DM and VTE.</p><p><b>METHODS AND RESULTS: </b>We included studies identified in PubMed, Web of Science, and CINAHL through 07/31/2014. We identified 19 studies that met our selection criteria. We pooled RRs using a random-effects model: the pooled RR for the association of DM with VTE was 1.10 (95% CI: 0.94-1.29). Between-study heterogeneity was explored with a forest plot, funnel plot, meta-regression, and a stratified analysis. Between-study heterogeneity was observed and not explained by study design, method of DM assessment, or degree of adjustment for confounding. Sensitivity analyses omitted one study at a time to assess the influence of any single study on the pooled estimate. These analyses indicated that one large study was highly influential; when this study was excluded, the pooled estimate increased and just reached statistical significance: 1.16 (95% CI: 1.01-1.34).</p><p><b>CONCLUSIONS: </b>This meta-analysis suggests either no association or a modest positive one between DM and VTE in the general population. DM is unlikely to play a major role in VTE development.</p> |
| DOI | 10.1016/j.diabres.2015.10.019 |
| Alternate Journal | Diabetes Res. Clin. Pract. |
| PubMed ID | 26612139 |
| PubMed Central ID | PMC4752919 |
| Grant List | R01 HL059367 / HL / NHLBI NIH HHS / United States T32 HL007779 / HL / NHLBI NIH HHS / United States T32HL007779 / HL / NHLBI NIH HHS / United States |