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Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study.
Tuesday,2015-04-07 12:53 America/Los_Angeles — zdrager
| Title | Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Agarwal, I, Arnold, A, Glazer, NL, Barasch, E, Djoussé, L, Fitzpatrick, AL, Gottdiener, JS, Ix, JH, Jensen, RA, Kizer, JR, Rimm, EB, Siscovick, DS, Tracy, RP, Wong, TY, Mukamal, KJ |
| Journal | Atherosclerosis |
| Volume | 239 |
| Issue | 2 |
| Pagination | 539-46 |
| Date Published | 2015 Apr |
| ISSN | 1879-1484 |
| Keywords | Aged, Ankle Brachial Index, Biomarkers, Brachial Artery, Carotid Artery Diseases, Carotid Intima-Media Thickness, Cross-Sectional Studies, Female, Fibrosis, Humans, Incidence, Male, Peptide Fragments, Peripheral Arterial Disease, Predictive Value of Tests, Procollagen, Prognosis, Prospective Studies, Retinal Diseases, Risk Factors, Transforming Growth Factor beta, United States, Vasodilation |
| Abstract | <p><b>OBJECTIVE: </b>Fibrosis has been implicated in a number of pathological, organ-based conditions of the liver, kidney, heart, and lungs. The objective of this study was to determine whether biomarkers of fibrosis are associated with vascular disease in the large and/or small vessels.</p><p><b>METHODS: </b>We evaluated the associations of two circulating biomarkers of fibrosis, transforming growth factor-β (TGF-β) and procollagen type III N-terminal propeptide (PIIINP), with incident peripheral artery disease (PAD) and subclinical macrovascular (carotid intima-media thickness, flow-mediated vasodilation, ankle-brachial index, retinal vein diameter), and microvascular (retinal artery diameter and retinopathy) disease among older adults in the Cardiovascular Health Study. We measured TGF-β and PIIINP from samples collected in 1996 and ascertained clinical PAD through 2011. Measurements of large and small vessels were collected between 1996 and 1998.</p><p><b>RESULTS: </b>After adjustment for sociodemographic, clinical, and biochemical risk factors, TGF-β was associated with incident PAD (hazard ratio [HR] = 1.36 per doubling of TGF-β, 95% confidence interval [CI] = 1.04, 1.78) and retinal venular diameter (1.63 μm per doubling of TGF-β, CI = 0.23, 3.02). PIIINP was not associated with incident PAD, but was associated with carotid intima-media thickness (0.102 mm per doubling of PIIINP, CI = 0.029, 0.174) and impaired brachial artery reactivity (-0.20% change per doubling of PIIINP, CI = -0.39, -0.02). Neither TGF-β nor PIIINP were associated with retinal arteriolar diameter or retinopathy.</p><p><b>CONCLUSIONS: </b>Serum concentrations of fibrosis-related biomarkers were associated with several measures of large vessel disease, including incident PAD, but not with small vessel disease. Fibrosis may contribute to large vessel atherosclerosis in older adults.</p> |
| DOI | 10.1016/j.atherosclerosis.2015.02.020 |
| Alternate Journal | Atherosclerosis |
| PubMed ID | 25725316 |
| PubMed Central ID | PMC4517825 |
| Grant List | AG023629 / AG / NIA NIH HHS / United States F30 HL118775 / HL / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States HL094555 / HL / NHLBI NIH HHS / United States HL118775 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States N01HC35129 / HC / NHLBI NIH HHS / United States N01HC45133 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85084 / HC / NHLBI NIH HHS / United States N01HC85085 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States |