You are here
Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults.
Wednesday,2015-03-04 14:17 America/Los_Angeles — zdrager
| Title | Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Varadhan, R, Yao, W, Matteini, A, Beamer, BA, Xue, Q-L, Yang, H, Manwani, B, Reiner, A, Jenny, N, Parekh, N, M Fallin, D, Newman, A, Bandeen-Roche, K, Tracy, R, Ferrucci, L, Walston, J |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 69 |
| Issue | 2 |
| Pagination | 165-73 |
| Date Published | 2014 Feb |
| ISSN | 1758-535X |
| Keywords | Aged, Aged, 80 and over, Biomarkers, C-Reactive Protein, Cohort Studies, Female, Humans, Inflammation, Interleukin 1 Receptor Antagonist Protein, Interleukin-18, Interleukin-6, Longevity, Male, Receptors, Tumor Necrosis Factor, Type I, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Individual measurements of inflammation have been utilized to assess adverse outcomes risk in older adults with varying degrees of success. This study was designed to identify biologically informed, aggregate measures of inflammation for optimal risk assessment and to inform further biological study of inflammatory pathways.</p><p><b>METHODS: </b>In total, 15 nuclear factor-kappa B-mediated pathway markers of inflammation were first measured in baseline serum samples of 1,155 older participants in the InCHIANTI population. Of these, C-reactive protein, interleukin-1-receptor antagonist, interleukin-6, interleukin-18, and soluble tumor necrosis factor-α receptor-1 were independent predictors of 5-year mortality. These five inflammatory markers were measured in baseline serum samples of 5,600 Cardiovascular Health Study participants. A weighted summary score, the first principal component summary score, and an inflammation index score were developed from these five log-transformed inflammatory markers, and their prediction of 10-year all-cause mortality was evaluated in Cardiovascular Health Study and then validated in InCHIANTI.</p><p><b>RESULTS: </b>The inflammation index score that included interleukin-6 and soluble tumor necrosis factor-α receptor-1 was the best predictor of 10-year all-cause mortality in Cardiovascular Health Study, after adjusting for age, sex, education, race, smoking, and body mass index (hazards ratio = 1.62; 95% CI: 1.54, 1.70) compared with all other single and combined measures. The inflammation index score was also the best predictor of mortality in the InCHIANTI validation study (hazards ratio 1.33; 95% CI: 1.17-1.52). Stratification by sex and CVD status further strengthened the association of inflammation index score with mortality.</p><p><b>CONCLUSION: </b>A simple additive index of serum interleukin-6 and soluble tumor necrosis factor-α receptor-1 best captures the effect of chronic inflammation on mortality in older adults among the 15 biomarkers measured.</p> |
| DOI | 10.1093/gerona/glt023 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 23689826 |
| PubMed Central ID | PMC4038244 |
| Grant List | AG-023629 / AG / NIA NIH HHS / United States AG-027058 / AG / NIA NIH HHS / United States AG-15928 / AG / NIA NIH HHS / United States AG-20098 / AG / NIA NIH HHS / United States HL080295 / HL / NHLBI NIH HHS / United States P30 AG021334 / AG / NIA NIH HHS / United States P30 AG021334 / AG / NIA NIH HHS / United States P30 AG024827 / AG / NIA NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01AG027236 / AG / NIA NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States |