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Gene expression in thiazide diuretic or statin users in relation to incident type 2 diabetes.
Wednesday,2015-03-04 14:14 America/Los_Angeles — zdrager
| Title | Gene expression in thiazide diuretic or statin users in relation to incident type 2 diabetes. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Suchy-Dicey, A, Heckbert, SR, Smith, NL, McKnight, B, Rotter, JI, Chen, YIda, Psaty, BM, Enquobahrie, DA |
| Journal | Int J Mol Epidemiol Genet |
| Volume | 5 |
| Issue | 1 |
| Pagination | 22-30 |
| Date Published | 2014 |
| ISSN | 1948-1756 |
| Abstract | Thiazide diuretics and statins are used to improve cardiovascular outcomes, but may also cause type 2 diabetes (T2DM), although mechanisms are unknown. Gene expression studies may facilitate understanding of these associations. Participants from ongoing population-based studies were sampled for these longitudinal studies of peripheral blood microarray gene expression, and followed to incident diabetes. All sampled subjects were statin or thiazide users. Those who developed diabetes during follow-up comprised cases (44 thiazide users; 19 statin users), and were matched to drug-using controls who did not develop diabetes on several factors. Supervised normalization, surrogate variable analyses removed technical bias and confounding. Differentially-expressed genes were those with a false discovery rate Q-value<0.05. Among thiazide users, diabetes cases had significantly different expression of CCL14 (down-regulated 6%, Q-value=0.0257), compared with controls. Among statin users, diabetes cases had marginal but insignificantly different expression of ZNF532 (up-regulated 15%, Q-value=0.0584), CXORF21 (up-regulated 11%, Q-value=0.0584), and ZNHIT3 (up-regulated 19%, Q-value=0.0959), compared with controls. These genes comprise potential targets for future expression or mechanistic research on medication-related diabetes development. |
| Alternate Journal | Int J Mol Epidemiol Genet |
| PubMed ID | 24596594 |
| PubMed Central ID | PMC3939004 |
| Grant List | P30 DK063491 / DK / NIDDK NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States |