You are here
Subclinical vascular disease burden and longer survival.
Wednesday,2015-03-04 13:58 America/Los_Angeles — zdrager
| Title | Subclinical vascular disease burden and longer survival. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Odden, MC, Yee, LM, Arnold, AM, Sanders, JL, Hirsch, C, DeFilippi, C, Kizer, JR, Inzitari, M, Newman, AB |
| Journal | J Am Geriatr Soc |
| Volume | 62 |
| Issue | 9 |
| Pagination | 1692-8 |
| Date Published | 2014 Sep |
| ISSN | 1532-5415 |
| Keywords | Aged, Aged, 80 and over, C-Reactive Protein, Carotid Intima-Media Thickness, Cohort Studies, Cystatin C, Depression, Diabetes Mellitus, Electrocardiography, Female, Humans, Inflammation, Kidney Diseases, Male, Smoking, Survival Analysis, United States, Vascular Diseases |
| Abstract | <p><b>OBJECTIVES: </b>To determine the contribution of gradations of subclinical vascular disease (SVD) to the likelihood of longer survival and to determine what allows some individuals with SVD to live longer.</p><p><b>DESIGN: </b>Cohort study.</p><p><b>SETTING: </b>Cardiovascular Health Study.</p><p><b>PARTICIPANTS: </b>Individuals born between June 30, 1918, and June 30, 1921 (N = 2,082; aged 70-75 at baseline (1992-93)).</p><p><b>MEASUREMENTS: </b>A SVD index was scored as 0 for no abnormalities, 1 for mild abnormalities, and 2 for severe abnormalities on ankle-arm index, electrocardiogram, and common carotid intima-media thickness measured at baseline. Survival groups were categorized as 80 and younger, 81 to 84, 85 to 89, and 90 and older.</p><p><b>RESULTS: </b>A 1-point lower SVD score was associated with 1.22 greater odds (95% confidence interval = 1.14-1.31) of longer survival, independent of potential confounders. This association was unchanged after adjustment for intermediate incident cardiovascular events. There was suggestion of an interaction between kidney function, smoking, and C-reactive protein and SVD; the association between SVD and longer survival appeared to be modestly greater in persons with poor kidney function, inflammation, or a history of smoking.</p><p><b>CONCLUSION: </b>A lower burden of SVD is associated with longer survival, independent of intermediate cardiovascular events. Abstinence from smoking, better kidney function, and lower inflammation may attenuate the effects of higher SVD and promote longer survival.</p> |
| DOI | 10.1111/jgs.13018 |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 25243681 |
| PubMed Central ID | PMC4176817 |
| Grant List | P30 AG024827 / AG / NIA NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States K01 AG039387 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States P30AG024827 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States R01 HL080295 / HL / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States K01AG039387 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States R56 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |