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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

Wednesday,2015-03-04 12:35 America/Los_Angeles — zdrager
TitleNovel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.
Publication TypeJournal Article
Year of Publication2015
AuthorsGottlieb, DJ, Hek, K, Chen, T-H, Watson, NF, Eiriksdottir, G, Byrne, EM, Cornelis, M, Warby, SC, Bandinelli, S, Cherkas, L, Evans, DS, Grabe, HJ, Lahti, J, Li, M, Lehtimäki, T, Lumley, T, Marciante, KD, Pérusse, L, Psaty, BM, Robbins, J, Tranah, GJ, Vink, JM, Wilk, JB, Stafford, JM, Bellis, C, Biffar, R, Bouchard, C, Cade, B, Curhan, GC, Eriksson, JG, Ewert, R, Ferrucci, L, Fülöp, T, Gehrman, PR, Goodloe, R, Harris, TB, Heath, AC, Hernandez, D, Hofman, A, Hottenga, J-J, Hunter, DJ, Jensen, MK, Johnson, AD, Kähönen, M, Kao, L, Kraft, P, Larkin, EK, Lauderdale, DS, Luik, AI, Medici, M, Montgomery, GW, Palotie, A, Patel, SR, Pistis, G, Porcu, E, Quaye, L, Raitakari, O, Redline, S, Rimm, EB, Rotter, JI, Smith, AV, Spector, TD, Teumer, A, Uitterlinden, AG, Vohl, M-C, Widen, E, Willemsen, G, Young, T, Zhang, X, Liu, Y, Blangero, J, Boomsma, DI, Gudnason, V, Hu, F, Mangino, M, Martin, NG, O'Connor, GT, Stone, KL, Tanaka, T, Viikari, J, Gharib, SA, Punjabi, NM, Räikkönen, K, Völzke, H, Mignot, E, Tiemeier, H
JournalMol Psychiatry
Volume20
Issue10
Pagination1232-9
Date Published2015 Oct
ISSN1476-5578
KeywordsAdult, African Americans, Aged, Dyssomnias, European Continental Ancestry Group, Female, Genetic Association Studies, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Self Report, Sleep
Abstract<p>Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease. </p>
DOI10.1038/mp.2014.133
Alternate JournalMol. Psychiatry
PubMed ID25469926
PubMed Central IDPMC4430294
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
RC2 MH089951 / MH / NIMH NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
U01 AR45632 / AR / NIAMS NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
CA98233 / CA / NCI NIH HHS / United States
UL1RR033176 / RR / NCRR NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
R01 AA007535 / AA / NIAAA NIH HHS / United States
R01 DK058845 / DK / NIDDK NIH HHS / United States
R01 AA014041 / AA / NIAAA NIH HHS / United States
R01 HL070848 / HL / NHLBI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
R01 MH066206 / MH / NIMH NIH HHS / United States
DK058845 / DK / NIDDK NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
AA13320 / AA / NIAAA NIH HHS / United States
N01 AG062101 / AG / NIA NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
R01 HL071194 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
RC2 MH089995 / MH / NIMH NIH HHS / United States
DK070756 / DK / NIDDK NIH HHS / United States
P50 AA011998 / AA / NIAAA NIH HHS / United States
R01 HL070847 / HL / NHLBI NIH HHS / United States
N02‐HL‐6‐4278 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
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R01 HL059367 / HL / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
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AA13321 / AA / NIAAA NIH HHS / United States
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R01 HL113338 / HL / NHLBI NIH HHS / United States
P01 DK070756 / DK / NIDDK NIH HHS / United States
N01 HC025195 / HC / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
U01 AR45647 / AR / NIAMS NIH HHS / United States
HG004399 / HG / NHGRI NIH HHS / United States
R01 AA013326 / AA / NIAAA NIH HHS / United States
R01 HL070842 / HL / NHLBI NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
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MH66206 / MH / NIMH NIH HHS / United States
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U01 AR45614 / AR / NIAMS NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
HL087652 / HL / NHLBI NIH HHS / United States
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WT089062 / / Wellcome Trust / United Kingdom
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U01 AR045614 / AR / NIAMS NIH HHS / United States
U01 AR45654 / AR / NIAMS NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
RC2ARO58973 / RC / CCR NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
U01 AR045654 / AR / NIAMS NIH HHS / United States
R01 AA013321 / AA / NIAAA NIH HHS / United States
R01 AG032098 / AG / NIA NIH HHS / United States
NS23724 / NS / NINDS NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
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HHSN268200782096C / HG / NHGRI NIH HHS / United States
/ / Intramural NIH HHS / United States
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079771 / / Wellcome Trust / United Kingdom
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R01 HL070841 / HL / NHLBI NIH HHS / United States
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AA11998 / AA / NIAAA NIH HHS / United States
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N01-HC-85080 / HC / NHLBI NIH HHS / United States
R01 HL070838 / HL / NHLBI NIH HHS / United States
1R01AG030474-01A1 / AG / NIA NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
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U01 CA098233 / CA / NCI NIH HHS / United States
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1UL1RR025011 / RR / NCRR NIH HHS / United States
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CA40356 / CA / NCI NIH HHS / United States
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DK063491 / DK / NIDDK NIH HHS / United States
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R01 HL035464 / HL / NHLBI NIH HHS / United States
RC2 AR058973 / AR / NIAMS NIH HHS / United States
U01 AR45580 / AR / NIAMS NIH HHS / United States
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R01 AR035582 / AR / NIAMS NIH HHS / United States
R01 AR35584 / AR / NIAMS NIH HHS / United States
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099194 / / Wellcome Trust / United Kingdom
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N01-HC-55018 / HC / NHLBI NIH HHS / United States
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R01 AG023629 / AG / NIA NIH HHS / United States
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