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Meta-analysis of loci associated with age at natural menopause in African-American women.
Wednesday,2015-03-04 12:13 America/Los_Angeles — zdrager
| Title | Meta-analysis of loci associated with age at natural menopause in African-American women. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Chen, CTL, Liu, C-T, Chen, GK, Andrews, JS, Arnold, AM, Dreyfus, J, Franceschini, N, Garcia, ME, Kerr, KF, Li, G, Lohman, KK, Musani, SK, Nalls, MA, Raffel, LJ, Smith, J, Ambrosone, CB, Bandera, EV, Bernstein, L, Britton, A, Brzyski, RG, Cappola, A, Carlson, CS, Couper, D, Deming, SL, Goodarzi, MO, Heiss, G, John, EM, Lu, X, Le Marchand, L, Marciante, K, McKnight, B, Millikan, R, Nock, NL, Olshan, AF, Press, MF, Vaiyda, D, Woods, NF, Taylor, HA, Zhao, W, Zheng, W, Evans, MK, Harris, TB, Henderson, BE, Kardia, SLR, Kooperberg, C, Liu, Y, Mosley, TH, Psaty, B, Wellons, M, Windham, BG, Zonderman, AB, Cupples, AL, Demerath, EW, Haiman, C, Murabito, JM, Rajkovic, A |
| Journal | Hum Mol Genet |
| Volume | 23 |
| Issue | 12 |
| Pagination | 3327-42 |
| Date Published | 2014 Jun 15 |
| ISSN | 1460-2083 |
| Keywords | African Americans, Age Factors, Chromosomes, Human, European Continental Ancestry Group, Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Menopause, United States |
| Abstract | <p>Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.</p> |
| DOI | 10.1093/hmg/ddu041 |
| Alternate Journal | Hum. Mol. Genet. |
| PubMed ID | 24493794 |
| PubMed Central ID | PMC4030781 |
| Grant List | UL1RR025005 / RR / NCRR NIH HHS / United States N02-HL-6-4278 / HL / NHLBI NIH HHS / United States UL1 RR033176 / RR / NCRR NIH HHS / United States UL1 TR000005 / TR / NCATS NIH HHS / United States UL1RR033176 / RR / NCRR NIH HHS / United States UL1TR000124 / TR / NCATS NIH HHS / United States P30 ES010126 / ES / NIEHS NIH HHS / United States Z01-AG000513 / AG / NIA NIH HHS / United States N01WH22110 / WH / WHI NIH HHS / United States R01-HL-071252 / HL / NHLBI NIH HHS / United States N01WH42129-32 / WH / WHI NIH HHS / United States R01-HL-071258 / HL / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States UL1-RR-025005 / RR / NCRR NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States HHSN268201100005C / / PHS HHS / United States R01-CA63464 / CA / NCI NIH HHS / United States HHSN268200900055C / / PHS HHS / United States N01AG62101 / AG / NIA NIH HHS / United States R01-HL-071250 / HL / NHLBI NIH HHS / United States N01WH32100-2 / WH / WHI NIH HHS / United States UL1-RR-024156 / RR / NCRR NIH HHS / United States HHSN268201100009C / / PHS HHS / United States P30 DK079637 / DK / NIDDK NIH HHS / United States N01WH32108-9 / WH / WHI NIH HHS / United States 1R01AG032098-01A1 / AG / NIA NIH HHS / United States HHSN268200625226C / / PHS HHS / United States R01-HL-071251 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States P50-CA58223 / CA / NCI NIH HHS / United States N01WH42107-26 / WH / WHI NIH HHS / United States HHSN268201100010C / / PHS HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States / / Intramural NIH HHS / United States N01 HC-55222 / HC / NHLBI NIH HHS / United States HHSN268201100008C / / PHS HHS / United States HHSN268201100012C / / PHS HHS / United States R01-HL-071259 / HL / NHLBI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States HL087660 / HL / NHLBI NIH HHS / United States N01WH32122 / WH / WHI NIH HHS / United States R01-HL-071205 / HL / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States HHSN268201100007C / / PHS HHS / United States N01-HC-95171 / HC / NHLBI NIH HHS / United States N01WH32105-6 / WH / WHI NIH HHS / United States HHSN5215810550000234 / / PHS HHS / United States N01WH32111-13 / WH / WHI NIH HHS / United States N01WH32118-32119 / WH / WHI NIH HHS / United States N01-HC-95172 / HC / NHLBI NIH HHS / United States HHSN268201100011C / / PHS HHS / United States DK063491 / DK / NIDDK NIH HHS / United States N01HC95159-69 / HC / NHLBI NIH HHS / United States UL1 TR001120 / TR / NCATS NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01AG62103 / AG / NIA NIH HHS / United States HHSN268201200036C / / PHS HHS / United States R01-HL-071051 / HL / NHLBI NIH HHS / United States HHSN268200782096C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01AG62106 / AG / NIA NIH HHS / United States HL54457 / HL / NHLBI NIH HHS / United States R21AG032598 / AG / NIA NIH HHS / United States N01-HC-85239 / HC / NHLBI NIH HHS / United States AG-023629 / AG / NIA NIH HHS / United States HHSN268201100006C / / PHS HHS / United States N01WH32115 / WH / WHI NIH HHS / United States N01-HC-95170 / HC / NHLBI NIH HHS / United States N01WH44221 / WH / WHI NIH HHS / United States R37-CA54281 / CA / NCI NIH HHS / United States P30-ES10126 / ES / NIEHS NIH HHS / United States N01WH24152 / WH / WHI NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States N01-HC-65226 / HC / NHLBI NIH HHS / United States |