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Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study.
Tuesday,2012-11-06 12:05 America/Los_Angeles — eenright
| Title | Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Newman, AB, Nieto, FJ, Guidry, U, Lind, BK, Redline, S, Pickering, TG, Quan, SF |
| Corporate/Institutional Authors | Sleep Heart Health Study Research Group, |
| Journal | Am J Epidemiol |
| Volume | 154 |
| Issue | 1 |
| Pagination | 50-9 |
| Date Published | 2001 Jul 01 |
| ISSN | 0002-9262 |
| Keywords | Adult, Aged, Analysis of Variance, Cardiovascular Diseases, Chi-Square Distribution, Cross-Sectional Studies, Female, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Polysomnography, Risk Factors, Sleep Apnea Syndromes, United States |
| Abstract | <p>Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors examined these relations in the Sleep Heart Health Study, a multiethnic cohort of 6,440 men and women over age 40 years conducted from October 1995 to February 1998 and characterized by home polysomnography. In 4,991 participants who were free of self-reported CVD at the time of the sleep study, moderate levels of sleep-disordered breathing were common, with a median Respiratory Disturbance Index (RDI) of 4.0 (interquartile range, 1.25-10.7). The level of RDI was associated cross-sectionally with age, body mass index, waist-to-hip ratio, hypertension, diabetes, and lipid levels. These relations were more pronounced in those under age 65 years than in those over age 65. Women under age 65 years with RDI in the higher quartiles were more obese than men with similar RDI. Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations. If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI.</p> |
| DOI | 10.1093/aje/154.1.50 |
| Alternate Journal | Am J Epidemiol |
| PubMed ID | 11434366 |
| Grant List | U01 HL53938 / HL / NHLBI NIH HHS / United States U01 HL53916 / HL / NHLBI NIH HHS / United States U01 HL053938 / HL / NHLBI NIH HHS / United States U01 HL53937 / HL / NHLBI NIH HHS / United States U01 HL53940 / HL / NHLBI NIH HHS / United States U01 HL53931 / HL / NHLBI NIH HHS / United States U01 HL53934 / HL / NHLBI NIH HHS / United States U01 HL53941 / HL / NHLBI NIH HHS / United States |