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Physical activity, inflammation, and volume of the aging brain.
Thursday,2014-05-29 14:12 America/Los_Angeles — poolea2
| Title | Physical activity, inflammation, and volume of the aging brain. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Braskie, MN, Boyle, CP, Rajagopalan, P, Gutman, BA, Toga, AW, Raji, CA, Tracy, RP, Kuller, LH, Becker, JT, Lopez, OL, Thompson, PM |
| Journal | Neuroscience |
| Volume | 273 |
| Pagination | 199-209 |
| Date Published | 2014 Jul 25 |
| ISSN | 1873-7544 |
| Keywords | Aged, Aged, 80 and over, Aging, Alzheimer Disease, Apolipoproteins E, Brain, Female, Humans, Inflammation, Longitudinal Studies, Magnetic Resonance Imaging, Male, Motor Activity, Neuroimmunomodulation, Neuropsychological Tests, Organ Size, Parietal Lobe, Surveys and Questionnaires, Tumor Necrosis Factor-alpha |
| Abstract | <p>Physical activity influences inflammation, and both affect brain structure and Alzheimer's disease (AD) risk. We hypothesized that older adults with greater reported physical activity intensity and lower serum levels of the inflammatory marker tumor necrosis factor α (TNFα) would have larger regional brain volumes on subsequent magnetic resonance imaging (MRI) scans. In 43 cognitively intact older adults (79.3±4.8 years) and 39 patients with AD (81.9±5.1 years at the time of MRI) participating in the Cardiovascular Health Study, we examined year-1 reported physical activity intensity, year-5 blood serum TNFα measures, and year-9 volumetric brain MRI scans. We examined how prior physical activity intensity and TNFα related to subsequent total and regional brain volumes. Physical activity intensity was measured using the modified Minnesota Leisure Time Physical Activities questionnaire at year 1 of the study, when all subjects included here were cognitively intact. Stability of measures was established for exercise intensity over 9 years and TNFα over 3 years in a subset of subjects who had these measurements at multiple time points. When considered together, more intense physical activity intensity and lower serum TNFα were both associated with greater total brain volume on follow-up MRI scans. TNFα, but not physical activity, was associated with regional volumes of the inferior parietal lobule, a region previously associated with inflammation in AD patients. Physical activity and TNFα may independently influence brain structure in older adults.</p> |
| DOI | 10.1016/j.neuroscience.2014.05.005 |
| Alternate Journal | Neuroscience |
| PubMed ID | 24836855 |
| PubMed Central ID | PMC4076831 |
| Grant List | P41 EB015922 / EB / NIBIB NIH HHS / United States N01-HC-80007 / HC / NHLBI NIH HHS / United States P50 AG005142 / AG / NIA NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 AG040060 / AG / NIA NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States AG020098 / AG / NIA NIH HHS / United States R56 AG020098 / AG / NIA NIH HHS / United States AG015928 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States R01 AG020098 / AG / NIA NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC75150 / HC / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States AG005133 / AG / NIA NIH HHS / United States AG040060 / AG / NIA NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |