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Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study.
Tuesday,2012-11-06 12:04 America/Los_Angeles — eenright
| Title | Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Shahar, E, Whitney, CW, Redline, S, Lee, ET, Newman, AB, Nieto, FJ, O'Connor, GT, Boland, LL, Schwartz, JE, Samet, JM |
| Journal | Am J Respir Crit Care Med |
| Volume | 163 |
| Issue | 1 |
| Pagination | 19-25 |
| Date Published | 2001 Jan |
| ISSN | 1073-449X |
| Keywords | Aged, Cardiovascular Diseases, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Sleep Apnea Syndromes |
| Abstract | <p>Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-living individuals who underwent overnight, unattended polysomnography at home. Sleep-disordered breathing was quantified by the apnea-hypopnea index (AHI)-the average number of apneas and hypopneas per hour of sleep. Mild to moderate disordered breathing during sleep was highly prevalent in the sample (median AHI: 4.4; interquartile range: 1.3 to 11.0). A total of 1,023 participants (16%) reported at least one manifestation of CVD (myocardial infarction, angina, coronary revascularization procedure, heart failure, or stroke). The multivariable-adjusted relative odds (95% CI) of prevalent CVD for the second, third, and fourth quartiles of the AHI (versus the first) were 0.98 (0.77-1.24), 1.28 (1.02-1.61), and 1.42 (1.13-1.78), respectively. Sleep-disordered breathing was associated more strongly with self-reported heart failure and stroke than with self-reported coronary heart disease: the relative odds (95% CI) of heart failure, stroke, and coronary heart disease (upper versus lower AHI quartile) were 2.38 (1.22-4.62), 1.58 (1.02- 2.46), and 1.27 (0.99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated.</p> |
| DOI | 10.1164/ajrccm.163.1.2001008 |
| Alternate Journal | Am J Respir Crit Care Med |
| PubMed ID | 11208620 |
| Grant List | UO1HL53940 / HL / NHLBI NIH HHS / United States P01 HL047540 / HL / NHLBI NIH HHS / United States UO1HL53941 / HL / NHLBI NIH HHS / United States UO1HL53931 / HL / NHLBI NIH HHS / United States UO1HL53916 / HL / NHLBI NIH HHS / United States UO1HL53938 / HL / NHLBI NIH HHS / United States UO1HL53937 / HL / NHLBI NIH HHS / United States UO1HL53934 / HL / NHLBI NIH HHS / United States |